Gallbladder cancer at a tertiary referral hospital in Peru: characteristics and outcomes in 20 years’ experience
Objective: Gallbladder cancer is a relatively uncommon neoplasm of the biliary system, characterized by a notably high mortality rate. Thisstudy aimed to identify prognostic factors for overall survival (OS) in Peruvian patients undergoing surgery for gallbladder cancer. Materials and methods: We c...
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| Format: | Article |
| Language: | English |
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Colegio Médico del Perú
2025-06-01
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| Series: | Acta Médica Peruana |
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| Online Access: | https://amp.cmp.org.pe/index.php/AMP/article/view/3259 |
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| author | Kamyla Mychele Olazo Cárdenas Juan Carlos Zea Burga Gabriel De La Cruz Ku Ramiro Fernández |
| author_facet | Kamyla Mychele Olazo Cárdenas Juan Carlos Zea Burga Gabriel De La Cruz Ku Ramiro Fernández |
| author_sort | Kamyla Mychele Olazo Cárdenas |
| collection | DOAJ |
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Objective: Gallbladder cancer is a relatively uncommon neoplasm of the biliary system, characterized by a notably high mortality rate. Thisstudy aimed to identify prognostic factors for overall survival (OS) in Peruvian patients undergoing surgery for gallbladder cancer. Materials and methods: We conducted a retrospective cohortstudy of patientswith gallbladder carcinoma who underwent surgery at the Instituto Nacional de Enfermedades Neoplásicas between 2000 and 2020. OS was analyzed using the Kaplan–Meier method, and prognostic factors were identified using Cox proportional hazardsregressionmodels. Results: A total of 64 patientswere included. Themedian agewas 62 years, and 75%were female.Most patientswere diagnosed at stage T3 (37.5%), and 25% had M1 stage disease. Additionally, 51.6% of tumors were moderately differentiated, and 71.9% were of the adenocarcinoma histologic subtype. With a median follow-up of 70 months, the 3-year OS rate was 45%. Independent prognostic factorsforOS included AJCC stage, high histological grade (vs. well/moderately differentiated; HR = 2.65, 95% CI: 1.06–6.63), and histologic subtype other than adenocarcinoma (HR = 3.10, 95% CI: 1.21–7.99). Conclusions: Prognostic factors associated with worse OS in Peruvian patients with gallbladder cancer undergoing surgery include AJCC stage, poorly differentiated histological grade, and histologic subtypes other than adenocarcinoma.
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| format | Article |
| id | doaj-art-eea78ef362064ffbbb51d46e7277b924 |
| institution | Matheson Library |
| issn | 1018-8800 1728-5917 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Colegio Médico del Perú |
| record_format | Article |
| series | Acta Médica Peruana |
| spelling | doaj-art-eea78ef362064ffbbb51d46e7277b9242025-06-28T17:25:39ZengColegio Médico del PerúActa Médica Peruana1018-88001728-59172025-06-0142210.35663/amp.2025.422.3259Gallbladder cancer at a tertiary referral hospital in Peru: characteristics and outcomes in 20 years’ experienceKamyla Mychele Olazo Cárdenas0https://orcid.org/0000-0003-4926-1490Juan Carlos Zea Burga1https://orcid.org/0000-0003-0226-6446Gabriel De La Cruz Ku2https://orcid.org/0000-0003-4203-3890Ramiro Fernández3https://orcid.org/0000-0002-2450-5447Universidad Científica del Sur, Lima, Perú.Universidad Científica del Sur, Lima, Perú.Universidad Científica del Sur, Lima, Perú.Universidad Científica del Sur, Lima, Perú. Objective: Gallbladder cancer is a relatively uncommon neoplasm of the biliary system, characterized by a notably high mortality rate. Thisstudy aimed to identify prognostic factors for overall survival (OS) in Peruvian patients undergoing surgery for gallbladder cancer. Materials and methods: We conducted a retrospective cohortstudy of patientswith gallbladder carcinoma who underwent surgery at the Instituto Nacional de Enfermedades Neoplásicas between 2000 and 2020. OS was analyzed using the Kaplan–Meier method, and prognostic factors were identified using Cox proportional hazardsregressionmodels. Results: A total of 64 patientswere included. Themedian agewas 62 years, and 75%were female.Most patientswere diagnosed at stage T3 (37.5%), and 25% had M1 stage disease. Additionally, 51.6% of tumors were moderately differentiated, and 71.9% were of the adenocarcinoma histologic subtype. With a median follow-up of 70 months, the 3-year OS rate was 45%. Independent prognostic factorsforOS included AJCC stage, high histological grade (vs. well/moderately differentiated; HR = 2.65, 95% CI: 1.06–6.63), and histologic subtype other than adenocarcinoma (HR = 3.10, 95% CI: 1.21–7.99). Conclusions: Prognostic factors associated with worse OS in Peruvian patients with gallbladder cancer undergoing surgery include AJCC stage, poorly differentiated histological grade, and histologic subtypes other than adenocarcinoma. https://amp.cmp.org.pe/index.php/AMP/article/view/3259Gallbladder NeoplasmsTreatment OutcomePrognosisLatin AmericaPeru |
| spellingShingle | Kamyla Mychele Olazo Cárdenas Juan Carlos Zea Burga Gabriel De La Cruz Ku Ramiro Fernández Gallbladder cancer at a tertiary referral hospital in Peru: characteristics and outcomes in 20 years’ experience Acta Médica Peruana Gallbladder Neoplasms Treatment Outcome Prognosis Latin America Peru |
| title | Gallbladder cancer at a tertiary referral hospital in Peru: characteristics and outcomes in 20 years’ experience |
| title_full | Gallbladder cancer at a tertiary referral hospital in Peru: characteristics and outcomes in 20 years’ experience |
| title_fullStr | Gallbladder cancer at a tertiary referral hospital in Peru: characteristics and outcomes in 20 years’ experience |
| title_full_unstemmed | Gallbladder cancer at a tertiary referral hospital in Peru: characteristics and outcomes in 20 years’ experience |
| title_short | Gallbladder cancer at a tertiary referral hospital in Peru: characteristics and outcomes in 20 years’ experience |
| title_sort | gallbladder cancer at a tertiary referral hospital in peru characteristics and outcomes in 20 years experience |
| topic | Gallbladder Neoplasms Treatment Outcome Prognosis Latin America Peru |
| url | https://amp.cmp.org.pe/index.php/AMP/article/view/3259 |
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