The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis
With attracting contemporary molecular-genetic and immunological research methods, it has been established that blood eosinophilia under pulmonary tuberculosis is mediated by hypersecretion eotaxin. Susceptibility to the emergence of eosinophilic blood reaction under tubercular infection is associat...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2012-12-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/913 |
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| author | K. O. Miheeva Yu. V. Kolobovnikova O. I. Urazova V. V. Novitsky O. V. Filinyuk M. D. Goncharov I. O. Naslednikova |
| author_facet | K. O. Miheeva Yu. V. Kolobovnikova O. I. Urazova V. V. Novitsky O. V. Filinyuk M. D. Goncharov I. O. Naslednikova |
| author_sort | K. O. Miheeva |
| collection | DOAJ |
| description | With attracting contemporary molecular-genetic and immunological research methods, it has been established that blood eosinophilia under pulmonary tuberculosis is mediated by hypersecretion eotaxin. Susceptibility to the emergence of eosinophilic blood reaction under tubercular infection is associated with the allele G and homozygous genotype GG of the polymorphic region A-384G of the gene eotaxin as well as with allele С and homozygous genotype СС polymorphism T-51C of the gene ССR3. |
| format | Article |
| id | doaj-art-ee75a11b1bc849dfb449b1daf2cb36c2 |
| institution | Matheson Library |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2012-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-ee75a11b1bc849dfb449b1daf2cb36c22025-08-04T16:45:35ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842012-12-0111621321510.20538/1682-0363-2012-6-213-215696The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosisK. O. Miheeva0Yu. V. Kolobovnikova1O. I. Urazova2V. V. Novitsky3O. V. Filinyuk4M. D. Goncharov5I. O. Naslednikova6Сибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскWith attracting contemporary molecular-genetic and immunological research methods, it has been established that blood eosinophilia under pulmonary tuberculosis is mediated by hypersecretion eotaxin. Susceptibility to the emergence of eosinophilic blood reaction under tubercular infection is associated with the allele G and homozygous genotype GG of the polymorphic region A-384G of the gene eotaxin as well as with allele С and homozygous genotype СС polymorphism T-51C of the gene ССR3.https://bulletin.ssmu.ru/jour/article/view/913eosinophiliacytokines, receptorseotaxingene polymorphism |
| spellingShingle | K. O. Miheeva Yu. V. Kolobovnikova O. I. Urazova V. V. Novitsky O. V. Filinyuk M. D. Goncharov I. O. Naslednikova The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis Бюллетень сибирской медицины eosinophilia cytokines , receptors eotaxin gene polymorphism |
| title | The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis |
| title_full | The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis |
| title_fullStr | The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis |
| title_full_unstemmed | The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis |
| title_short | The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis |
| title_sort | role of polymorphism of genes eotaxin 384 and ccr3 51 in formation of blood eosinophilia under pulmonary tuberculosis |
| topic | eosinophilia cytokines , receptors eotaxin gene polymorphism |
| url | https://bulletin.ssmu.ru/jour/article/view/913 |
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