Outcome And Etiology of Patients Admitted with Acute Viral Hepatitis At Naimat Begum Hamdard University Hospital Karachi
Background:Acute viral hepatitis is a significant public health challenge in Pakistan, particularly in urban centers like Karachi, where poor sanitation and healthcare infrastructure exacerbate its burden. This study aims to evaluate the etiology, clinical presentations, laboratory findings, and ou...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ziauddin University
2025-07-01
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| Series: | Pakistan Journal of Medicine and Dentistry |
| Subjects: | |
| Online Access: | https://ojs.zu.edu.pk/pjmd/article/view/3461 |
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| Summary: | Background:Acute viral hepatitis is a significant public health challenge in Pakistan, particularly in urban centers like Karachi, where poor sanitation and healthcare infrastructure exacerbate its burden. This study aims to evaluate the etiology, clinical presentations, laboratory findings, and outcomes of patients admitted with acute viral hepatitis.
Methods: A retrospective observational study was conducted at Hamdard University Hospital, Karachi, including 275 patients admitted with acute viral hepatitis between January 2020 and July 2023. Data were collected from medical records, including demographics, clinical symptoms, laboratory parameters (ALT, AST, bilirubin, PT/INR), and outcomes. Patients were categorized based on the etiologies of hepatitis A, B, and E. Statistical analysis was performed to identify significant differences among groups.
Results: Hepatitis A accounted for 62.9% of cases, followed by hepatitis E (33.8%) and hepatitis B (3.3%). The mean age of patients was 19.14 years, with a significant male predominance in hepatitis A (70.6%) and higher female prevalence in hepatitis E (41.1%). The mean SGPT, SGOT, and bilirubin levels were 1562.15 U/L, 1358.42 U/L, and 7.21 mg/dL, respectively, with no significant differences across etiologies. Liver failure occurred in 6.2% of cases, and 10.2% required ICU admission. Hepatitis A cases peaked in July (77.8%) and December (68.8%), while hepatitis E showed the highest incidence in September (54.1%), corresponding to the monsoon and post-monsoon periods.
Conclusion: Hepatitis A and E are the predominant causes of acute viral hepatitis in Karachi, associated with significant liver dysfunction.
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| ISSN: | 2313-7371 2308-2593 |