The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria
Abstract Background: Staphylococcus aureus bacteriuria (SABU) may represent bacteremia in a subset of patients. We describe the impact of a microbiology alert recommending follow-up blood cultures (FUBC) for patients with SABU in a large integrated health system. Methods: We conducted a quasi-e...
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Cambridge University Press
2025-01-01
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| Series: | Antimicrobial Stewardship & Healthcare Epidemiology |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2732494X25100673/type/journal_article |
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| author | Jared Olson Vincent Anella Brandon J. Webb Andrew T. Pavia Emily A. Thorell Adam L. Hersh Dustin Waters |
| author_facet | Jared Olson Vincent Anella Brandon J. Webb Andrew T. Pavia Emily A. Thorell Adam L. Hersh Dustin Waters |
| author_sort | Jared Olson |
| collection | DOAJ |
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Abstract
Background:
Staphylococcus aureus bacteriuria (SABU) may represent bacteremia in a subset of patients. We describe the impact of a microbiology alert recommending follow-up blood cultures (FUBC) for patients with SABU in a large integrated health system.
Methods:
We conducted a quasi-experimental implementation study in adult ambulatory patients with documented SABU. We excluded patients with confirmed SAB up to 14 days prior to index SABU culture and with blood cultures obtained on the day of SABU. The primary outcome was rate of FUBC (collected between 1 and 5 days of SABU) among all cases of SABU. Secondary outcomes included percentage of patients with early SAB (collected between 1 and 5 days of SABU). We used interrupted time series analysis to compare rates of FUBC pre vs postintervention.
Results:
A total of 2 540 patients were identified; 1 213 (48%) were male. By the end of the postintervention period, the rate of FUBC (20.6%) had increased by 6.3 percentage points (P = .005) compared to the counterfactual (14.2%) had no intervention taken place (44.5% relative increase). Early SAB detection due to FUBC increased from .6% preintervention to 2.0% postintervention (P = .004).
Conclusion:
The microbiology alert initiative increased FUBC in patients with SABU by 44%, but the overall rate of FUBC remained low. The intervention increased early SAB detection. Risk-targeted strategies are needed to optimize FUBC collection in patients with SABU.
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| format | Article |
| id | doaj-art-edab76201fb94fc8a62a4af27b9a16f0 |
| institution | Matheson Library |
| issn | 2732-494X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Antimicrobial Stewardship & Healthcare Epidemiology |
| spelling | doaj-art-edab76201fb94fc8a62a4af27b9a16f02025-07-17T12:29:14ZengCambridge University PressAntimicrobial Stewardship & Healthcare Epidemiology2732-494X2025-01-01510.1017/ash.2025.10067The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuriaJared Olson0https://orcid.org/0000-0002-3281-9614Vincent Anella1https://orcid.org/0009-0005-6230-1022Brandon J. Webb2https://orcid.org/0000-0002-1799-3315Andrew T. Pavia3https://orcid.org/0000-0002-3066-580XEmily A. Thorell4Adam L. Hersh5Dustin Waters6https://orcid.org/0000-0003-4500-9810Division of Infectious Diseases, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA Department of Pharmacy, Primary Children’s Hospital, Salt Lake City, UT, USADepartment of Pharmacy, Primary Children’s Hospital, Salt Lake City, UT, USADivision of Infectious Diseases, Intermountain Medical Center, Murray, UT, USADivision of Infectious Diseases, Department of Pediatrics, University of Utah, Salt Lake City, UT, USADivision of Infectious Diseases, Department of Pediatrics, University of Utah, Salt Lake City, UT, USADivision of Infectious Diseases, Department of Pediatrics, University of Utah, Salt Lake City, UT, USADepartment of Pharmacy, McKay Dee Hospital, Ogden, UT, USA Abstract Background: Staphylococcus aureus bacteriuria (SABU) may represent bacteremia in a subset of patients. We describe the impact of a microbiology alert recommending follow-up blood cultures (FUBC) for patients with SABU in a large integrated health system. Methods: We conducted a quasi-experimental implementation study in adult ambulatory patients with documented SABU. We excluded patients with confirmed SAB up to 14 days prior to index SABU culture and with blood cultures obtained on the day of SABU. The primary outcome was rate of FUBC (collected between 1 and 5 days of SABU) among all cases of SABU. Secondary outcomes included percentage of patients with early SAB (collected between 1 and 5 days of SABU). We used interrupted time series analysis to compare rates of FUBC pre vs postintervention. Results: A total of 2 540 patients were identified; 1 213 (48%) were male. By the end of the postintervention period, the rate of FUBC (20.6%) had increased by 6.3 percentage points (P = .005) compared to the counterfactual (14.2%) had no intervention taken place (44.5% relative increase). Early SAB detection due to FUBC increased from .6% preintervention to 2.0% postintervention (P = .004). Conclusion: The microbiology alert initiative increased FUBC in patients with SABU by 44%, but the overall rate of FUBC remained low. The intervention increased early SAB detection. Risk-targeted strategies are needed to optimize FUBC collection in patients with SABU. https://www.cambridge.org/core/product/identifier/S2732494X25100673/type/journal_article |
| spellingShingle | Jared Olson Vincent Anella Brandon J. Webb Andrew T. Pavia Emily A. Thorell Adam L. Hersh Dustin Waters The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria Antimicrobial Stewardship & Healthcare Epidemiology |
| title | The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria |
| title_full | The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria |
| title_fullStr | The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria |
| title_full_unstemmed | The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria |
| title_short | The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria |
| title_sort | impact of an intervention to increase follow up blood cultures for patients with staphylococcus aureus bacteriuria |
| url | https://www.cambridge.org/core/product/identifier/S2732494X25100673/type/journal_article |
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