THE EFFICIENCY OF TOLERANT (PASSIVE) ADAPTATION UNDER THE CONDITIONS OF EXPERIMENTAL POLYTRAUMA
The model of multiple skeletal injuries was reproduced in two groups. 22 animals of the 1st group had stabilization of the right forearm bones and left shin with spoke external fixation device of 2 subsystems with followed osteotomy of the bones of respective segment in the middle third under genera...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2013-04-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/1465 |
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| author | M. L. Lebed M. G. Kirpichenko S. N. Bocharov V. V. Gumanenko |
| author_facet | M. L. Lebed M. G. Kirpichenko S. N. Bocharov V. V. Gumanenko |
| author_sort | M. L. Lebed |
| collection | DOAJ |
| description | The model of multiple skeletal injuries was reproduced in two groups. 22 animals of the 1st group had stabilization of the right forearm bones and left shin with spoke external fixation device of 2 subsystems with followed osteotomy of the bones of respective segment in the middle third under general anesthesia. During the experiment the injection of dexamethasone and adrenaline during the first twenty-four hours after multiple skeletal injuries prevented the reduce the intensity of the metabolic processes, that was proved by close to initial values of oxygen consumption and carbon dioxide emissions. But to the third day there was no any difference in the metabolic activity in rabbits having and not having adrenaline and dexamethasone. The animals had adrenaline and dexamethasone turned to be in more severe clinical situation. As a result of «normal» intensity of metabolic processes in rabbits during the near time period after trauma there was decrease of survival from 45,5 % to 7,7 %. |
| format | Article |
| id | doaj-art-ed3989f8f53145b88f2ca8f31d519a8c |
| institution | Matheson Library |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2013-04-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-ed3989f8f53145b88f2ca8f31d519a8c2025-07-28T14:03:13ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962013-04-0102(2)1481511411THE EFFICIENCY OF TOLERANT (PASSIVE) ADAPTATION UNDER THE CONDITIONS OF EXPERIMENTAL POLYTRAUMAM. L. Lebed0M. G. Kirpichenko1S. N. Bocharov2V. V. Gumanenko3Scientific Center of Reconstructive and Restorative Surgery SB RAMSScientific Center of Reconstructive and Restorative Surgery SB RAMSScientific Center of Reconstructive and Restorative Surgery SB RAMS; Irkutsk State Medical UniversityIrkutsk State Medical UniversityThe model of multiple skeletal injuries was reproduced in two groups. 22 animals of the 1st group had stabilization of the right forearm bones and left shin with spoke external fixation device of 2 subsystems with followed osteotomy of the bones of respective segment in the middle third under general anesthesia. During the experiment the injection of dexamethasone and adrenaline during the first twenty-four hours after multiple skeletal injuries prevented the reduce the intensity of the metabolic processes, that was proved by close to initial values of oxygen consumption and carbon dioxide emissions. But to the third day there was no any difference in the metabolic activity in rabbits having and not having adrenaline and dexamethasone. The animals had adrenaline and dexamethasone turned to be in more severe clinical situation. As a result of «normal» intensity of metabolic processes in rabbits during the near time period after trauma there was decrease of survival from 45,5 % to 7,7 %.https://www.actabiomedica.ru/jour/article/view/1465multiple skeletal injuriestolerancemortalityadrenalinedexamethasone |
| spellingShingle | M. L. Lebed M. G. Kirpichenko S. N. Bocharov V. V. Gumanenko THE EFFICIENCY OF TOLERANT (PASSIVE) ADAPTATION UNDER THE CONDITIONS OF EXPERIMENTAL POLYTRAUMA Acta Biomedica Scientifica multiple skeletal injuries tolerance mortality adrenaline dexamethasone |
| title | THE EFFICIENCY OF TOLERANT (PASSIVE) ADAPTATION UNDER THE CONDITIONS OF EXPERIMENTAL POLYTRAUMA |
| title_full | THE EFFICIENCY OF TOLERANT (PASSIVE) ADAPTATION UNDER THE CONDITIONS OF EXPERIMENTAL POLYTRAUMA |
| title_fullStr | THE EFFICIENCY OF TOLERANT (PASSIVE) ADAPTATION UNDER THE CONDITIONS OF EXPERIMENTAL POLYTRAUMA |
| title_full_unstemmed | THE EFFICIENCY OF TOLERANT (PASSIVE) ADAPTATION UNDER THE CONDITIONS OF EXPERIMENTAL POLYTRAUMA |
| title_short | THE EFFICIENCY OF TOLERANT (PASSIVE) ADAPTATION UNDER THE CONDITIONS OF EXPERIMENTAL POLYTRAUMA |
| title_sort | efficiency of tolerant passive adaptation under the conditions of experimental polytrauma |
| topic | multiple skeletal injuries tolerance mortality adrenaline dexamethasone |
| url | https://www.actabiomedica.ru/jour/article/view/1465 |
| work_keys_str_mv | AT mllebed theefficiencyoftolerantpassiveadaptationundertheconditionsofexperimentalpolytrauma AT mgkirpichenko theefficiencyoftolerantpassiveadaptationundertheconditionsofexperimentalpolytrauma AT snbocharov theefficiencyoftolerantpassiveadaptationundertheconditionsofexperimentalpolytrauma AT vvgumanenko theefficiencyoftolerantpassiveadaptationundertheconditionsofexperimentalpolytrauma AT mllebed efficiencyoftolerantpassiveadaptationundertheconditionsofexperimentalpolytrauma AT mgkirpichenko efficiencyoftolerantpassiveadaptationundertheconditionsofexperimentalpolytrauma AT snbocharov efficiencyoftolerantpassiveadaptationundertheconditionsofexperimentalpolytrauma AT vvgumanenko efficiencyoftolerantpassiveadaptationundertheconditionsofexperimentalpolytrauma |