Antibiotic Elution from Cement Spacers and Its Influencing Factors
Antibiotic-loaded cement spacers play a crucial role in two-stage revision arthroplasty of infected total hip and knee prostheses. There is still controversy regarding whether the elution from antibiotic-loaded cement spacers is greater than the MIC for a prolonged time between stages. Therefore, th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/7/705 |
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| author | Bernd Fink Kevin D. Tetsworth |
| author_facet | Bernd Fink Kevin D. Tetsworth |
| author_sort | Bernd Fink |
| collection | DOAJ |
| description | Antibiotic-loaded cement spacers play a crucial role in two-stage revision arthroplasty of infected total hip and knee prostheses. There is still controversy regarding whether the elution from antibiotic-loaded cement spacers is greater than the MIC for a prolonged time between stages. Therefore, the aim of the current review was to determine how long spacers elute antibiotics above the MIC for most causative microorganisms, as well as to evaluate what factors influence that elution. Independent of methodological differences and weaknesses of the studies themselves, several study results indicate that after an early peak of antibiotic release from the spacer in the first 1 to 2 days (followed by a gradual decline), a sufficient release above the MIC for most causative bacteria continues for 6 to 12 weeks. |
| format | Article |
| id | doaj-art-ed18d5dba0234d4fb8f30bb6e897a9db |
| institution | Matheson Library |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-ed18d5dba0234d4fb8f30bb6e897a9db2025-07-25T13:11:25ZengMDPI AGAntibiotics2079-63822025-07-0114770510.3390/antibiotics14070705Antibiotic Elution from Cement Spacers and Its Influencing FactorsBernd Fink0Kevin D. Tetsworth1Department for Joint Replacement, Rheumatoid and General Orthopaedics, Orthopaedic Clinic Markgröningen, Kurt-Lindemann-Weg 10, 71706 Markgröningen, GermanyDepartment of Orthopaedic Surgery, Royal Brisbane and Women’s Hospital, Level 7 NHB, Herston, QLD 4029, AustraliaAntibiotic-loaded cement spacers play a crucial role in two-stage revision arthroplasty of infected total hip and knee prostheses. There is still controversy regarding whether the elution from antibiotic-loaded cement spacers is greater than the MIC for a prolonged time between stages. Therefore, the aim of the current review was to determine how long spacers elute antibiotics above the MIC for most causative microorganisms, as well as to evaluate what factors influence that elution. Independent of methodological differences and weaknesses of the studies themselves, several study results indicate that after an early peak of antibiotic release from the spacer in the first 1 to 2 days (followed by a gradual decline), a sufficient release above the MIC for most causative bacteria continues for 6 to 12 weeks.https://www.mdpi.com/2079-6382/14/7/705periprosthetic joint infectionspacerantibiotic elutionantibiotic-loaded bone cement |
| spellingShingle | Bernd Fink Kevin D. Tetsworth Antibiotic Elution from Cement Spacers and Its Influencing Factors Antibiotics periprosthetic joint infection spacer antibiotic elution antibiotic-loaded bone cement |
| title | Antibiotic Elution from Cement Spacers and Its Influencing Factors |
| title_full | Antibiotic Elution from Cement Spacers and Its Influencing Factors |
| title_fullStr | Antibiotic Elution from Cement Spacers and Its Influencing Factors |
| title_full_unstemmed | Antibiotic Elution from Cement Spacers and Its Influencing Factors |
| title_short | Antibiotic Elution from Cement Spacers and Its Influencing Factors |
| title_sort | antibiotic elution from cement spacers and its influencing factors |
| topic | periprosthetic joint infection spacer antibiotic elution antibiotic-loaded bone cement |
| url | https://www.mdpi.com/2079-6382/14/7/705 |
| work_keys_str_mv | AT berndfink antibioticelutionfromcementspacersanditsinfluencingfactors AT kevindtetsworth antibioticelutionfromcementspacersanditsinfluencingfactors |