Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women
Breast cancer is the most commonly diagnosed cancer and remains one of the main reasons of cancer-related mortality in women worldwide. KRAS variant rs61764370 (T>G) is associated with an increased risk of occurrence of many cancers, Here The case-control study was accomplished on 135 women inclu...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Baghdad, College of Science for Women
2020-05-01
|
| Series: | مجلة بغداد للعلوم |
| Subjects: | |
| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3573 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839595804126347264 |
|---|---|
| author | Al-Haddad et al. |
| author_facet | Al-Haddad et al. |
| author_sort | Al-Haddad et al. |
| collection | DOAJ |
| description | Breast cancer is the most commonly diagnosed cancer and remains one of the main reasons of cancer-related mortality in women worldwide. KRAS variant rs61764370 (T>G) is associated with an increased risk of occurrence of many cancers, Here The case-control study was accomplished on 135 women including 45 women with breast cancer patients, 45 women with benign breast lesions and 45 healthy women to analyze the association of KRAS variant rs (61764370 T>G) with breast cancer. LCS 6 variant in KRAS gene was amplified by using specific primers, then genotype was detected after sequencing the PCR products. The results showed that the genotype and allele frequency of TT and GT allele of KRAS gene were statistically non-significant (p< 0.01) among breast cancer patients and breast benign lesions compared with healthy controls in Iraqi women. |
| format | Article |
| id | doaj-art-ecd3dcb4a7544d3bb0af11afe818fdbc |
| institution | Matheson Library |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2020-05-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-ecd3dcb4a7544d3bb0af11afe818fdbc2025-08-02T22:43:35ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862020-05-0117210.21123/bsj.2020.17.2.0426Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi WomenAl-Haddad et al.0Medical molecular genetic/ Biotechnology Department/Al-Nahrain universityBreast cancer is the most commonly diagnosed cancer and remains one of the main reasons of cancer-related mortality in women worldwide. KRAS variant rs61764370 (T>G) is associated with an increased risk of occurrence of many cancers, Here The case-control study was accomplished on 135 women including 45 women with breast cancer patients, 45 women with benign breast lesions and 45 healthy women to analyze the association of KRAS variant rs (61764370 T>G) with breast cancer. LCS 6 variant in KRAS gene was amplified by using specific primers, then genotype was detected after sequencing the PCR products. The results showed that the genotype and allele frequency of TT and GT allele of KRAS gene were statistically non-significant (p< 0.01) among breast cancer patients and breast benign lesions compared with healthy controls in Iraqi women.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3573Breast benign lesions, Breast cancer, KRAS, rs 61764370 |
| spellingShingle | Al-Haddad et al. Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women مجلة بغداد للعلوم Breast benign lesions, Breast cancer, KRAS, rs 61764370 |
| title | Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women |
| title_full | Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women |
| title_fullStr | Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women |
| title_full_unstemmed | Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women |
| title_short | Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women |
| title_sort | lack of association between lcs6 variant in kras gene with the occurrence of breast tumors in iraqi women |
| topic | Breast benign lesions, Breast cancer, KRAS, rs 61764370 |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3573 |
| work_keys_str_mv | AT alhaddadetal lackofassociationbetweenlcs6variantinkrasgenewiththeoccurrenceofbreasttumorsiniraqiwomen |