Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study
ABSTRACT Introduction The pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin‐6 (IL‐6); IL‐6 triggers intracellular pathways through interaction with the IL‐6 receptor (IL‐6R). This study aimed to determine the association of sing...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.70073 |
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| author | Pavla Izakovicova Simona Slezakova Tereza Deissova Hana Poskerova Petra Borilova Linhartova Ladislav Dusek Katerina Kankova Lydie Izakovicova Holla |
| author_facet | Pavla Izakovicova Simona Slezakova Tereza Deissova Hana Poskerova Petra Borilova Linhartova Ladislav Dusek Katerina Kankova Lydie Izakovicova Holla |
| author_sort | Pavla Izakovicova |
| collection | DOAJ |
| description | ABSTRACT Introduction The pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin‐6 (IL‐6); IL‐6 triggers intracellular pathways through interaction with the IL‐6 receptor (IL‐6R). This study aimed to determine the association of single nucleotide polymorphisms (SNPs) IL‐6 −597G/A (rs1800797), −572G/C (rs1800796), −174G/C (rs1800795), its receptor (IL‐6R) Asp358Ala (+48892A/C, rs2228145) and DM or its complications in the Czech population. Materials and Methods In total, 669 subjects participated in this case‐control study, including 167 controls, 119 patients with type 1 DM (T1DM), and 383 patients with type 2 DM (T2DM). The subjects were monitored for glycemia, glycated hemoglobin, lipid profile, glomerular filtration rate (GFR), and common complications, such as diabetic nephropathy (DN), retinopathy (DR), (poly)neuropathy (DPN), and periodontitis (P). Results Frequencies of the IL‐6 and IL‐6R alleles or genotypes, and IL‐6 haplotypes were similar between the controls and the patients with T1DM or T2DM (P > 0.05). However, lower values of GFR were observed in diabetic patients with IL‐6 −174CC homozygotes compared to other (CG and GG) genotypes (P ≤ 0.05). In addition, the IL‐6R Asp358Ala variant was associated with DN (P = 0.031, OR = 1.74, 95% CI: 1.05–2.89). After subclassification according to the type of DM, the significant association of the IL‐6R polymorphism with DN was only found in T1DM (P = 0.013, OR = 2.90, 95% CI: 1.25–6.71). Conclusions This study implies a significant relationship between the IL‐6R Asp358Ala polymorphism and DN in Czech T1DM patients. |
| format | Article |
| id | doaj-art-eca2280fe2bc49b286c4393e7c46f67f |
| institution | Matheson Library |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
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| series | Journal of Diabetes Investigation |
| spelling | doaj-art-eca2280fe2bc49b286c4393e7c46f67f2025-08-01T12:51:37ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-08-011681463147210.1111/jdi.70073Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control studyPavla Izakovicova0Simona Slezakova1Tereza Deissova2Hana Poskerova3Petra Borilova Linhartova4Ladislav Dusek5Katerina Kankova6Lydie Izakovicova Holla7Faculty of Medicine Masaryk University Brno Czech RepublicClinic of Stomatology, Faculty of Medicine, Institution Shared with St. Anne's University Hospital Masaryk University Brno Czech RepublicDepartment of Pathophysiology, Faculty of Medicine Masaryk University Brno Czech RepublicClinic of Stomatology, Faculty of Medicine, Institution Shared with St. Anne's University Hospital Masaryk University Brno Czech RepublicClinic of Stomatology, Faculty of Medicine, Institution Shared with St. Anne's University Hospital Masaryk University Brno Czech RepublicInstitute of Biostatistics and Analyses, Faculty of Medicine Masaryk University Brno Czech RepublicDepartment of Pathophysiology, Faculty of Medicine Masaryk University Brno Czech RepublicClinic of Stomatology, Faculty of Medicine, Institution Shared with St. Anne's University Hospital Masaryk University Brno Czech RepublicABSTRACT Introduction The pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin‐6 (IL‐6); IL‐6 triggers intracellular pathways through interaction with the IL‐6 receptor (IL‐6R). This study aimed to determine the association of single nucleotide polymorphisms (SNPs) IL‐6 −597G/A (rs1800797), −572G/C (rs1800796), −174G/C (rs1800795), its receptor (IL‐6R) Asp358Ala (+48892A/C, rs2228145) and DM or its complications in the Czech population. Materials and Methods In total, 669 subjects participated in this case‐control study, including 167 controls, 119 patients with type 1 DM (T1DM), and 383 patients with type 2 DM (T2DM). The subjects were monitored for glycemia, glycated hemoglobin, lipid profile, glomerular filtration rate (GFR), and common complications, such as diabetic nephropathy (DN), retinopathy (DR), (poly)neuropathy (DPN), and periodontitis (P). Results Frequencies of the IL‐6 and IL‐6R alleles or genotypes, and IL‐6 haplotypes were similar between the controls and the patients with T1DM or T2DM (P > 0.05). However, lower values of GFR were observed in diabetic patients with IL‐6 −174CC homozygotes compared to other (CG and GG) genotypes (P ≤ 0.05). In addition, the IL‐6R Asp358Ala variant was associated with DN (P = 0.031, OR = 1.74, 95% CI: 1.05–2.89). After subclassification according to the type of DM, the significant association of the IL‐6R polymorphism with DN was only found in T1DM (P = 0.013, OR = 2.90, 95% CI: 1.25–6.71). Conclusions This study implies a significant relationship between the IL‐6R Asp358Ala polymorphism and DN in Czech T1DM patients.https://doi.org/10.1111/jdi.70073Diabetic nephropathyIL‐6Polymorphisms |
| spellingShingle | Pavla Izakovicova Simona Slezakova Tereza Deissova Hana Poskerova Petra Borilova Linhartova Ladislav Dusek Katerina Kankova Lydie Izakovicova Holla Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study Journal of Diabetes Investigation Diabetic nephropathy IL‐6 Polymorphisms |
| title | Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study |
| title_full | Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study |
| title_fullStr | Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study |
| title_full_unstemmed | Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study |
| title_short | Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study |
| title_sort | association of the il 6r rs2228145 polymorphism with diabetic nephropathy a case control study |
| topic | Diabetic nephropathy IL‐6 Polymorphisms |
| url | https://doi.org/10.1111/jdi.70073 |
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