Plant-derived extracellular vesicles as a natural drug delivery platform for glioblastoma therapy: A dual role in preserving endothelial integrity while modulating the tumor microenvironment

Glioblastoma (GBM) is the most aggressive primary brain tumor, with limited treatment options due to the restrictive blood-brain barrier (BBB) and the heterogeneity of the blood-tumor barrier (BTB). Temozolomide (TMZ), the standard chemotherapy, suffers from poor BBB permeability, rapid degradation,...

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Bibliographic Details
Main Authors: Lishan Cui, Giordano Perini, Antonio Minopoli, Valentina Palmieri, Marco De Spirito, Massimiliano Papi
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:International Journal of Pharmaceutics: X
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Online Access:http://www.sciencedirect.com/science/article/pii/S2590156725000349
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