Two fatal cases of endothall poisoning
Background Endothall is a protein phosphatase 5 inhibitor used as an herbicide however scant reports of human exposure are associated with high lethality.Case series: We describe two cases of endothall toxicity in Melbourne, Victoria. Case 1 was a 75‐year‐old male who had died following an accidenta...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Toxicology Communications |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/24734306.2024.2407235 |
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| author | Siba J. Sulaeman Joanna Glengarry Paul Bedford Patrick O’Sullivan Joe‐Anthony Rotella |
| author_facet | Siba J. Sulaeman Joanna Glengarry Paul Bedford Patrick O’Sullivan Joe‐Anthony Rotella |
| author_sort | Siba J. Sulaeman |
| collection | DOAJ |
| description | Background Endothall is a protein phosphatase 5 inhibitor used as an herbicide however scant reports of human exposure are associated with high lethality.Case series: We describe two cases of endothall toxicity in Melbourne, Victoria. Case 1 was a 75‐year‐old male who had died following an accidental ingestion of a mouthful of endothall (175 g/L). He developed a severe metabolic acidosis with cardiac arrest following a gastroscopy demonstrating severe haemorrhagic gastritis and oesophagitis. Case 2 was a 29‐year‐old male, who was presented after ingesting 100 mL of endothall (175 g/L) with suicidal intent and who died in less than 24 h despite intensive treatment including continuous renal replacement therapy.Discussion Endothall is a rare but lethal poisoning in humans post ingestion that causes both corrosion and multi‐organ failure. Whilst there are limited data, early intensive care management appears necessary, no published cases have survived longer than 24 h.Conclusion Endothall is highly lethal in small quantities despite current best measures; therefore, public health measures to restrict access are strongly recommended. |
| format | Article |
| id | doaj-art-eb1d7e35e7c84bd389f80b92d2d37a4b |
| institution | Matheson Library |
| issn | 2473-4306 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Toxicology Communications |
| spelling | doaj-art-eb1d7e35e7c84bd389f80b92d2d37a4b2025-07-07T12:16:54ZengTaylor & Francis GroupToxicology Communications2473-43062024-12-018110.1080/24734306.2024.2407235Two fatal cases of endothall poisoningSiba J. Sulaeman0Joanna Glengarry1Paul Bedford2Patrick O’Sullivan3Joe‐Anthony Rotella4Department of Emergency Medicine, Frankston, AustraliaForensic Services, Victorian Institute of Forensic Medicine, Southbank, AustraliaForensic Services, Victorian Institute of Forensic Medicine, Southbank, AustraliaDepartment of Intensive Care, Northern Health, Epping, AustraliaVictorian Poisons Information Centre, Austin Health, Heidelberg, AustraliaBackground Endothall is a protein phosphatase 5 inhibitor used as an herbicide however scant reports of human exposure are associated with high lethality.Case series: We describe two cases of endothall toxicity in Melbourne, Victoria. Case 1 was a 75‐year‐old male who had died following an accidental ingestion of a mouthful of endothall (175 g/L). He developed a severe metabolic acidosis with cardiac arrest following a gastroscopy demonstrating severe haemorrhagic gastritis and oesophagitis. Case 2 was a 29‐year‐old male, who was presented after ingesting 100 mL of endothall (175 g/L) with suicidal intent and who died in less than 24 h despite intensive treatment including continuous renal replacement therapy.Discussion Endothall is a rare but lethal poisoning in humans post ingestion that causes both corrosion and multi‐organ failure. Whilst there are limited data, early intensive care management appears necessary, no published cases have survived longer than 24 h.Conclusion Endothall is highly lethal in small quantities despite current best measures; therefore, public health measures to restrict access are strongly recommended.https://www.tandfonline.com/doi/10.1080/24734306.2024.2407235Endothallcase reportfatalityherbicidepoisoning |
| spellingShingle | Siba J. Sulaeman Joanna Glengarry Paul Bedford Patrick O’Sullivan Joe‐Anthony Rotella Two fatal cases of endothall poisoning Toxicology Communications Endothall case report fatality herbicide poisoning |
| title | Two fatal cases of endothall poisoning |
| title_full | Two fatal cases of endothall poisoning |
| title_fullStr | Two fatal cases of endothall poisoning |
| title_full_unstemmed | Two fatal cases of endothall poisoning |
| title_short | Two fatal cases of endothall poisoning |
| title_sort | two fatal cases of endothall poisoning |
| topic | Endothall case report fatality herbicide poisoning |
| url | https://www.tandfonline.com/doi/10.1080/24734306.2024.2407235 |
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