Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

IntroductionAlpha-synuclein (α-Syn) aggregation, transmission, and contribution to neurotoxicity represent central mechanisms underlying Parkinson’s disease. The plant alkaloid “nicotine” was reported to attenuate α-Syn aggregation in different models, but its precise mode of action remains unclear....

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Main Authors: Mohamed Bilal Fares, Omar Alijevic, Stephanie Johne, Cassia Overk, Makoto Hashimoto, Athanasios Kondylis, Anthony Adame, Remi Dulize, Dariusz Peric, Catherine Nury, James Battey, Emmanuel Guedj, Nicolas Sierro, Damian Mc Hugh, Edward Rockenstein, Changyoun Kim, Robert A. Rissman, Julia Hoeng, Manuel C. Peitsch, Eliezer Masliah, Carole Mathis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Neuroscience
Subjects:
synucleinopathy
induced pluripotent stem cell (iPSC)
transgenic mice
nicotine
nicotinic acetylcholine receptors (nAChR)
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1239009/full
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