Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case report
Background: Multiple malignant neoplasms in pediatric patients are rare, posing diagnostic and therapeutic challenges. This case report details a 12-year-old girl with a Yolk Sac Tumor (YST) found to have a Solid Pseudopapillary Neoplasm (SPN) of the pancreas, highlighting management complexities. C...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Pediatric Hematology Oncology Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468124525000257 |
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| author | A. Roggero L. Piro D. Paoloni F. Palo S. Avanzini V. Capra P. De Marco S. Sorrentino E. Arkhangelskaya J. Ferro V.G. Vellone M. Conte |
| author_facet | A. Roggero L. Piro D. Paoloni F. Palo S. Avanzini V. Capra P. De Marco S. Sorrentino E. Arkhangelskaya J. Ferro V.G. Vellone M. Conte |
| author_sort | A. Roggero |
| collection | DOAJ |
| description | Background: Multiple malignant neoplasms in pediatric patients are rare, posing diagnostic and therapeutic challenges. This case report details a 12-year-old girl with a Yolk Sac Tumor (YST) found to have a Solid Pseudopapillary Neoplasm (SPN) of the pancreas, highlighting management complexities. Case report: A 12-year-old girl presented with pelvic pain and dysuria. Imaging revealed a right ovarian mass, confirmed as YST. A partial ovariectomy was performed. Persistent abdominal pain led to further investigation, revealing a pancreatic lesion and residual ovarian mass. Multidisciplinary management included salpingo-oophorectomy and distal pancreatectomy, achieving complete tumor resection. Genetic testing, including Whole Exome Sequencing of 400 cancer predisposition genes, found no significant variants. Conclusion: The synchronous occurrence of YST and SPN in pediatric patients, without pathogenic variants, is extremely rare. Management involved surgery, chemotherapy for YST, and individualized SPN treatment. Long-term follow-up is essential due to the malignancy potential of both tumors. |
| format | Article |
| id | doaj-art-ead9bc6a173f4333b3a8ce23eb69f143 |
| institution | Matheson Library |
| issn | 2468-1245 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatric Hematology Oncology Journal |
| spelling | doaj-art-ead9bc6a173f4333b3a8ce23eb69f1432025-06-25T04:51:59ZengElsevierPediatric Hematology Oncology Journal2468-12452025-06-01102100457Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case reportA. Roggero0L. Piro1D. Paoloni2F. Palo3S. Avanzini4V. Capra5P. De Marco6S. Sorrentino7E. Arkhangelskaya8J. Ferro9V.G. Vellone10M. Conte11Pediatric Surgery Department, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genoa, Italy; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Science, University of Genoa, Genoa, Italy; Corresponding author. Via Gerolamo Gaslini 5, 16147, Genoa, Italy.Pediatric Surgery Department, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genoa, Italy; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Science, University of Genoa, Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Science, University of Genoa, Genoa, Italy; Unit of Pediatric Oncology, Giannina Gaslini Children's Hospital, Genova, ItalyPediatric Surgery Department, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genoa, ItalyPediatric Surgery Department, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genoa, ItalyMedical Genetics Unit, IRCCS Giannina Gaslini Institute, Genoa, ItalyMedical Genetics Unit, IRCCS Giannina Gaslini Institute, Genoa, ItalyUnit of Pediatric Oncology, Giannina Gaslini Children's Hospital, Genova, ItalyDepartment of Radiology, Institute G. Gaslini, Genoa, ItalyPathology Unit, IRCCS Istituto Giannina Gaslini, Genoa, ItalyPathology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy; Department of Integrated Surgical and Diagnostic Sciences (DISC), University of Genoa, ItalyUnit of Pediatric Oncology, Giannina Gaslini Children's Hospital, Genova, ItalyBackground: Multiple malignant neoplasms in pediatric patients are rare, posing diagnostic and therapeutic challenges. This case report details a 12-year-old girl with a Yolk Sac Tumor (YST) found to have a Solid Pseudopapillary Neoplasm (SPN) of the pancreas, highlighting management complexities. Case report: A 12-year-old girl presented with pelvic pain and dysuria. Imaging revealed a right ovarian mass, confirmed as YST. A partial ovariectomy was performed. Persistent abdominal pain led to further investigation, revealing a pancreatic lesion and residual ovarian mass. Multidisciplinary management included salpingo-oophorectomy and distal pancreatectomy, achieving complete tumor resection. Genetic testing, including Whole Exome Sequencing of 400 cancer predisposition genes, found no significant variants. Conclusion: The synchronous occurrence of YST and SPN in pediatric patients, without pathogenic variants, is extremely rare. Management involved surgery, chemotherapy for YST, and individualized SPN treatment. Long-term follow-up is essential due to the malignancy potential of both tumors.http://www.sciencedirect.com/science/article/pii/S2468124525000257 |
| spellingShingle | A. Roggero L. Piro D. Paoloni F. Palo S. Avanzini V. Capra P. De Marco S. Sorrentino E. Arkhangelskaya J. Ferro V.G. Vellone M. Conte Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case report Pediatric Hematology Oncology Journal |
| title | Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case report |
| title_full | Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case report |
| title_fullStr | Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case report |
| title_full_unstemmed | Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case report |
| title_short | Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case report |
| title_sort | co occurrence of ovarian yolk sac tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient a case report |
| url | http://www.sciencedirect.com/science/article/pii/S2468124525000257 |
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