Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression

QR Code

Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression

BackgroundRenal failure and dysfunction remain one of the most significant morbidities impacting patient’s life. Effective treatments still lack in the context of an increasing number of patients with renal failure. This study aims to investigate the impact of growth differentiation factor 15 (GDF15...

Full description

Saved in:

Bibliographic Details
Main Authors:	Cuilin Zhu, Qing Liu, Yale Su, Yixin Zhang, Aanal Patel, Adam Greasley, Jifu Jiang, Douglas Quan, Weiping Min, Kexiang Liu, Xiufen Zheng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	GDF15 ischemia reperfusion injury kidney apoptosis inflammation circular RNA
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1577625/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A Systems Analysis of Reverse Channel Dynamics and Government Subsidies in Sustainable Remanufacturing
by: Ting Ji, et al.
Published: (2025-07-01)

A field-based crop and land use map over Sanjiang plain in Heilongjiang derived from multi-temporal imagery of Landsat7-ETM+
by: Herman Eerens, et al.
Published: (2003-09-01)

TFCNet: A Hybrid Architecture for Multi-Task Restoration of Complex Underwater Optical Images
by: Shengya Zhao, et al.
Published: (2025-05-01)

Investigating the Role of GDF-15 in Diabetes and Obesity: A Comprehensive Analysis of a Cohort from the KDEP Study
by: Jehad Abubaker, et al.
Published: (2025-06-01)

GDF-15 Levels in Gouty Arthritis and Correlations with Decreasing Renal Function: A Clinical Study
by: Osman Cure, et al.
Published: (2025-07-01)

Experimental Study on the Influence of Jet Dynamic Pressure Based on a New Confining Pressure Control System
by: Zhou Shijie, et al.
Published: (2025-06-01)

GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis
by: Teresa Rubio-Tomás, et al.
Published: (2025-09-01)

Predictors of futile recanalisation in patients with large infarct: a post-hoc analysis of the ANGEL-ASPECT trial
by: Zhongrong Miao, et al.

Cardiac-targeted FGF4 encapsulated nanoliposomes improve acute myocardial injury induced by ischemia-reperfusion and adriamycin in in vitro and in vivo models
by: Kaihao Wang, et al.
Published: (2025-08-01)

Polymorphism of genes CAST, GH, GDF9 of sheep of the Dagestan mountain breed
by: A. A. Ozdemirov, et al.
Published: (2021-07-01)

A novel secreted protein FgHrip1 from Fusarium graminearum triggers immune responses in plants
by: Zhenchao Fu, et al.
Published: (2024-11-01)

Electrochemical Cells with the Liquid Electrolyte in the Study of Semiconductor, Metallic and Oxide Systems
by: Vassiliev, Valery, et al.
Published: (2012)

MAFF mitigates oxidative stress and pyroptosis in cardiopulmonary bypass-induced myocardium injury
by: Lei Yuan, et al.
Published: (2025-07-01)

Effects of herbicide diclofop-methyl on oxidative stress and microcystin release in cyanobacterium Microsystis aeruginosa
by: Ye Jing, et al.
Published: (2014-05-01)

THE ROLE OF GROWTH DIFFERENTIATION FACTOR 11 (GDF11) IN REGULATION OF LIPID METAbOLISM AND CARDIOHEMODYNAMIC FUNCTIONS IN ESSENTIAL HYPERTENSION PATIENTS IN MODERATE EFFORT ExERCISES
by: E. S. Guseva, et al.
Published: (2018-05-01)

Endoplasmic reticulum stress of astrocytes in paraventricular nucleus of hypothalamus promotes ventricular electrical instability after acute myocardial infarction in rats
by: Yuhang Yang, et al.
Published: (2025-07-01)

Development of the GDF-TRACK-AKI Score for Predicting Acute Kidney Injury in Patients with Rhabdomyolysis Due to Excessive Exercise or Trauma
by: Oğuzhan Zengin, et al.
Published: (2025-06-01)

Frailty and survival of patients with renal cell carcinoma: A meta-analysis
by: Longye Zhang, et al.
Published: (2025-07-01)

Solvothermal synthesis of rhombic shape GdF<sub>3</sub>:Tb<sup>3+</sup> nanoparticles for biomedical applications
by: E. A. Kuchma, et al.
Published: (2023-06-01)

Anti-inflammatory Therapy Before Reperfusion Therapy in Patients with Ischemic Vascular Disease on the Incidence of Ischemic Reperfusion Injury: An Evidence-Based Case Report
by: Dono Antono, et al.
Published: (2025-04-01)

Effect of Sodium Dehydroacetate Treatment on the Preservation and Endophyte Community Composition of Macadamia Nut
by: HE Peng, WANG Xiaoyu, ZHANG Tao, SONG Haiyun, CHEN Xi, ZHANG Xiufen, TANG Xiuhua, TU Xinghao, QIN Jian, WANG Wenlin
Published: (2025-05-01)

Exploring Carbon Emission Reduction Pathways: Analysis of Energy Conservation Potential in Yangtze River Economic Belt
by: Weiping Cui, et al.
Published: (2025-07-01)

Impact of Multiple Factors on Temperature Distribution and Output Performance in Dusty Photovoltaic Modules: Implications for Sustainable Solar Energy
by: Weiping Zhao, et al.
Published: (2025-06-01)

Cu-DHM nanozymes treat flap ischemia-reperfusion injury by amplifying immune modulation in a cascade manner and inhibiting cell apoptosis
by: Xinyu Zhao, et al.
Published: (2025-09-01)

Orthogonal Time-Frequency Multiplexing With 2D Hermitian Symmetry for Optical-Wireless Communications
by: Jie Zhong, et al.
Published: (2020-01-01)

Position measurement and output feedback tracking method of hydraulic servo system based on pressure sensor
by: Wang Weiping, et al.
Published: (2025-07-01)

SHP2 inhibitor specifically suppresses the stemness of KRAS-mutant non-small cell lung cancer cells
by: Lei Jiang, et al.
Published: (2019-12-01)

Population Viability Analysis Revealed the Vulnerability of Yangtze Finless Porpoise (<i>Neophocaena asiaeorientalis</i>) in Poyang Lake
by: Bin Wu, et al.
Published: (2025-06-01)

A systematic review of silymarin and silibinin mechanisms for attenuating cerebral ischemia-reperfusion injuries
by: Hossein Mardani-Nafchi, et al.
Published: (2025-07-01)

Alleviative Effects of Ciprofol on Hepatic Ischemia/Reperfusion Injury Through Inhibiting Macrophage Polarization
by: Hanjian Chen, et al.
Published: (2025-07-01)

Nomograms predicting survival and patterns of failure in patients with cervical cancer treated with concurrent chemoradiotherapy: A special focus on lymph nodes metastases.
by: Weiping Wang, et al.
Published: (2019-01-01)

Puerarin alleviates renal ischemia/reperfusion injury by inhibiting apoptosis and endoplasmic reticulum stress via Nrf2/HO-1 pathway
by: Jingsong Wang, et al.
Published: (2025-02-01)

The role of oxidative stress in spinal cord ischemia reperfusion injury: mechanisms and therapeutic implications
by: Yu Xing, et al.
Published: (2025-06-01)

Cross-sectional mechanical characteristics and sensitivity analysis of unbonded flexible risers under axial loads
by: Xiansheng Zhang, et al.
Published: (2025-08-01)

Axial-FNet: skin cancer image segmentation model based on fuzzy convolution combined with gated axial self-attention
by: JIANG Shu, et al.
Published: (2025-06-01)

Pathogenesis and clinical significance of reperfusion arrhythmias in acute myocardial infarctio
by: V. E. Oleynikov, et al.
Published: (2024-10-01)

High expression of mitosis-related gene CCDC14 could predict a better prognosis for bladder cancer patients
by: Haojie Dai, et al.
Published: (2025-08-01)

Measurement and analysis of moment of inertia using torsional pendulum method with air damping consideration
by: MA Weiping, et al.
Published: (2025-01-01)

Understudied targets of the ischemia-reperfusion injury pathogenesis in liver transplantation
by: P. O. Svishcheva, et al.
Published: (2024-06-01)

THE PLACE FOR SYSTEMIC THROMBOLYSIS IN MODERN REPERFUSION METHODS FOR MYOCARDIAL INFARCTION
by: O. V. Averkov, et al.
Published: (2014-09-01)