NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL
Purpose: to study argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) in proliferating cells in relationship between the clinical and morphological parameters and survival in squamous cell lung carcinoma. Materials and methods: One hundred and thirteen surgical specim...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/143 |
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| author | D. S. Kobyakov A. F. Lazarev Е. L. Lushnikova L. М. Nepomnyaschikh |
| author_facet | D. S. Kobyakov A. F. Lazarev Е. L. Lushnikova L. М. Nepomnyaschikh |
| author_sort | D. S. Kobyakov |
| collection | DOAJ |
| description | Purpose: to study argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) in proliferating cells in relationship between the clinical and morphological parameters and survival in squamous cell lung carcinoma. Materials and methods: One hundred and thirteen surgical specimens of squamous cell lung cancer were studied using double staining for Ki-67 antigen (MIB-1 clone, DAKO) by immunohistochemistry and for Ag-ЯОР-proteins with silver nitrate. results: In squamous cell carcinoma, the Ag-NOR area in Ki-67 positive cells correlated with the clinical and morphological parameters: parameter T, the greatest tumor size, parameter N, stage of the disease and tumor differentiation. When the area of Ag-ЯОР-proteins in Ki-67 positive cells was small, the long-term survival rates were higher. The Ag-ЯОР area in Ki-67 positive cells is an independent prognostic factor in squamous cell lung cancer. |
| format | Article |
| id | doaj-art-ea9d21a1e739432c9993e90c9edf67e2 |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-ea9d21a1e739432c9993e90c9edf67e22025-08-04T10:33:35ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01125863143NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVALD. S. Kobyakov0A. F. Lazarev1Е. L. Lushnikova2L. М. Nepomnyaschikh3Kogalym Municipal Hospital, KogalymAltai branch of the N.N. Blokhin Russian Cancer Research Center, RAMS, BarnaulResearch Institute of Regional Pathology and Pathomorphology of Siberian Division of the Russian Academy of Medical Scienсеs, NovosibirskResearch Institute of Regional Pathology and Pathomorphology of Siberian Division of the Russian Academy of Medical Scienсеs, NovosibirskPurpose: to study argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) in proliferating cells in relationship between the clinical and morphological parameters and survival in squamous cell lung carcinoma. Materials and methods: One hundred and thirteen surgical specimens of squamous cell lung cancer were studied using double staining for Ki-67 antigen (MIB-1 clone, DAKO) by immunohistochemistry and for Ag-ЯОР-proteins with silver nitrate. results: In squamous cell carcinoma, the Ag-NOR area in Ki-67 positive cells correlated with the clinical and morphological parameters: parameter T, the greatest tumor size, parameter N, stage of the disease and tumor differentiation. When the area of Ag-ЯОР-proteins in Ki-67 positive cells was small, the long-term survival rates were higher. The Ag-ЯОР area in Ki-67 positive cells is an independent prognostic factor in squamous cell lung cancer.https://www.siboncoj.ru/jour/article/view/143nuclear organizerski-67survivalsquamous cell lung carcinoma |
| spellingShingle | D. S. Kobyakov A. F. Lazarev Е. L. Lushnikova L. М. Nepomnyaschikh NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL Сибирский онкологический журнал nuclear organizers ki-67 survival squamous cell lung carcinoma |
| title | NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL |
| title_full | NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL |
| title_fullStr | NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL |
| title_full_unstemmed | NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL |
| title_short | NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL |
| title_sort | nuclear organizers in ki 67 positive cells of squamous cell lung cancer clinical morphological parallels and survival |
| topic | nuclear organizers ki-67 survival squamous cell lung carcinoma |
| url | https://www.siboncoj.ru/jour/article/view/143 |
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