Ameliorative effects of Sesamum Indicum aqueous extract on Letrozole-induced polycystic ovary syndrome in adult female rats and formulation of sesame syrup
Background: In this study, we explored the potential of Sesamum indicum L. aqueous extract (AES) in treating Polycystic ovary syndrome (PCOS) in female rats and developing a medicinal syrup from it. Experimental procedure: We conducted experiments on 42 adult Sprague Dawley female rats, dividing the...
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Elsevier
2025-07-01
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| Series: | Journal of Traditional and Complementary Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411024000518 |
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| author | Zeynab Khosrowpour Shamim Sahranavard Fatemeh Jafari Mojgan Tansaz Shirin Fahimi Mehrdad Faizi |
| author_facet | Zeynab Khosrowpour Shamim Sahranavard Fatemeh Jafari Mojgan Tansaz Shirin Fahimi Mehrdad Faizi |
| author_sort | Zeynab Khosrowpour |
| collection | DOAJ |
| description | Background: In this study, we explored the potential of Sesamum indicum L. aqueous extract (AES) in treating Polycystic ovary syndrome (PCOS) in female rats and developing a medicinal syrup from it. Experimental procedure: We conducted experiments on 42 adult Sprague Dawley female rats, dividing them into six groups. The control group received a 1% carboxymethyl cellulose vehicle, while the other groups were given letrozole orally for 21 days followed by administration of AES, metformin, and distilled water after 28 days of PCOS induction. Results: Results showed that after letrozole administration, PCOS was confirmed by irregular estrous cycles and increased LH and testosterone levels. The AES and metformin improved estrus cyclicity in rats compared to the PCOS group. Additionally, LH levels and LH/FSH ratio were significantly reduced in AES and metformin groups, while testosterone levels decreased and estradiol levels increased. Histological studies revealed normal follicular development in these groups with fewer cystic follicles. Conclusion: In conclusion, the AES showed promise in alleviating PCOS symptoms due to its phytochemical components such as β-sitosterol, campesterol, and stigmasterol, and sesquiterpenes with phytoestrogenic, androgenic and antiinflammatory effects. The 400 mg/kg dose was found to be the most effective in this experiment. |
| format | Article |
| id | doaj-art-ea9251e95f4b42f58baf7a701056f2a0 |
| institution | Matheson Library |
| issn | 2225-4110 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
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| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj-art-ea9251e95f4b42f58baf7a701056f2a02025-06-28T05:30:14ZengElsevierJournal of Traditional and Complementary Medicine2225-41102025-07-01154369379Ameliorative effects of Sesamum Indicum aqueous extract on Letrozole-induced polycystic ovary syndrome in adult female rats and formulation of sesame syrupZeynab Khosrowpour0Shamim Sahranavard1Fatemeh Jafari2Mojgan Tansaz3Shirin Fahimi4Mehrdad Faizi5Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranTraditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranTraditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Traditional Pharmacy and Persian Medicine, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding author. School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, No.8 Shams Alley, Vali-e-Asr Street, Tehran, P.O.Box 1516745811, Iran.Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: In this study, we explored the potential of Sesamum indicum L. aqueous extract (AES) in treating Polycystic ovary syndrome (PCOS) in female rats and developing a medicinal syrup from it. Experimental procedure: We conducted experiments on 42 adult Sprague Dawley female rats, dividing them into six groups. The control group received a 1% carboxymethyl cellulose vehicle, while the other groups were given letrozole orally for 21 days followed by administration of AES, metformin, and distilled water after 28 days of PCOS induction. Results: Results showed that after letrozole administration, PCOS was confirmed by irregular estrous cycles and increased LH and testosterone levels. The AES and metformin improved estrus cyclicity in rats compared to the PCOS group. Additionally, LH levels and LH/FSH ratio were significantly reduced in AES and metformin groups, while testosterone levels decreased and estradiol levels increased. Histological studies revealed normal follicular development in these groups with fewer cystic follicles. Conclusion: In conclusion, the AES showed promise in alleviating PCOS symptoms due to its phytochemical components such as β-sitosterol, campesterol, and stigmasterol, and sesquiterpenes with phytoestrogenic, androgenic and antiinflammatory effects. The 400 mg/kg dose was found to be the most effective in this experiment.http://www.sciencedirect.com/science/article/pii/S2225411024000518Polycystic ovarian syndromeLetrozoleSesamum indicumHerbal formulationMetformin |
| spellingShingle | Zeynab Khosrowpour Shamim Sahranavard Fatemeh Jafari Mojgan Tansaz Shirin Fahimi Mehrdad Faizi Ameliorative effects of Sesamum Indicum aqueous extract on Letrozole-induced polycystic ovary syndrome in adult female rats and formulation of sesame syrup Journal of Traditional and Complementary Medicine Polycystic ovarian syndrome Letrozole Sesamum indicum Herbal formulation Metformin |
| title | Ameliorative effects of Sesamum Indicum aqueous extract on Letrozole-induced polycystic ovary syndrome in adult female rats and formulation of sesame syrup |
| title_full | Ameliorative effects of Sesamum Indicum aqueous extract on Letrozole-induced polycystic ovary syndrome in adult female rats and formulation of sesame syrup |
| title_fullStr | Ameliorative effects of Sesamum Indicum aqueous extract on Letrozole-induced polycystic ovary syndrome in adult female rats and formulation of sesame syrup |
| title_full_unstemmed | Ameliorative effects of Sesamum Indicum aqueous extract on Letrozole-induced polycystic ovary syndrome in adult female rats and formulation of sesame syrup |
| title_short | Ameliorative effects of Sesamum Indicum aqueous extract on Letrozole-induced polycystic ovary syndrome in adult female rats and formulation of sesame syrup |
| title_sort | ameliorative effects of sesamum indicum aqueous extract on letrozole induced polycystic ovary syndrome in adult female rats and formulation of sesame syrup |
| topic | Polycystic ovarian syndrome Letrozole Sesamum indicum Herbal formulation Metformin |
| url | http://www.sciencedirect.com/science/article/pii/S2225411024000518 |
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