Method for quantitative analysis of the marker substrate ABCB1-protein fexofenadine in Caco-2 cell lysate

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Method for quantitative analysis of the marker substrate ABCB1-protein fexofenadine in Caco-2 cell lysate

One way to analyze the activity of the ABCB1 protein is to assess the accumulation of its substrate fexofenadine (F.) inside the test cells. The goal is to develop and validate a method for the quantitative analysis of F. in Caco-2 cell lysate using HPLC-MS/MS. Materials and methods. Caco-2 cell lys...

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Bibliographic Details
Main Authors:	M. A. Kopanitsa, Yu. S. Tranova, I. V. Chernykh, A. V. Shchulkin, P. Yu. Mylnikov, O. V. Kalinkina, E. N. Yakusheva
Format:	Article
Language:	Russian
Published:	LLC “Publisher OKI” 2023-07-01
Series:	Фармакокинетика и Фармакодинамика
Subjects:	hplc-ms/ms fexofenadine abcb1 protein caco-2 cell lysate
Online Access:	https://www.pharmacokinetica.ru/jour/article/view/373
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