Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa
The spread of resistance to insecticides, such as pyrethroids, in Aedes vectors increases the risk of spread of arboviral diseases. In Gabon, the insecticide resistance profiles of Ae. aegypti and Ae. albopictus species remain poorly known. During a study to monitor the dynamics of Aedes populations...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2025-01-01
|
| Series: | Parasite |
| Subjects: | |
| Online Access: | https://www.parasite-journal.org/articles/parasite/full_html/2025/01/parasite240173/parasite240173.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839639392836124672 |
|---|---|
| author | Obame-Nkoghe Judicaël Kondji Faël Moudoumi Diouf El Hadji Thiaw Omar Niangui Brad Ghaven Ondo-Oyono Arnauld Okomo-Nguema Yasmine Longo-Pendy Neil Michel Mounioko Franck Makanga Boris Kamgang Basile Paupy Christophe Kengne Pierre Otomo Patricks Voua Niang El Hadji Amadou |
| author_facet | Obame-Nkoghe Judicaël Kondji Faël Moudoumi Diouf El Hadji Thiaw Omar Niangui Brad Ghaven Ondo-Oyono Arnauld Okomo-Nguema Yasmine Longo-Pendy Neil Michel Mounioko Franck Makanga Boris Kamgang Basile Paupy Christophe Kengne Pierre Otomo Patricks Voua Niang El Hadji Amadou |
| author_sort | Obame-Nkoghe Judicaël |
| collection | DOAJ |
| description | The spread of resistance to insecticides, such as pyrethroids, in Aedes vectors increases the risk of spread of arboviral diseases. In Gabon, the insecticide resistance profiles of Ae. aegypti and Ae. albopictus species remain poorly known. During a study to monitor the dynamics of Aedes populations in Franceville, in south-east Gabon, the resistance profiles of these two species to pyrethroids, organophosphates and carbamates were assessed. Susceptibility tests on adults and synergist tests with piperonyl butoxide (PBO) were carried out as per the World Health Organization protocol. The results showed that Ae. aegypti and Ae. albopictus were susceptible to permethrin, pirimiphos-methyl and bendiocarb. However, both species were resistant to deltamethrin (mortality: 67% for Ae. aegypti; 33% for Ae. albopictus). Exposure to a 5-fold dose of deltamethrin increased mortality to 100% and 91% for Ae. aegypti and Ae. albopictus, respectively. Resistance to alpha-cypermethrin was also recorded (mortality: 82% for Ae. aegypti; 64.6% for Ae. albopictus). Pre-exposure to PBO resulted in the restoration of susceptibility to deltamethrin and alpha-cypermethrin for Ae. aegypti, and a significant increase in mortality for Ae. albopictus. These data provide the first evidence of pyrethroid resistance in Aedes in Gabon and could help to establish more effective control measures against arbovirus vectors. |
| format | Article |
| id | doaj-art-e9f76f07a31544609735ff958d7fc33a |
| institution | Matheson Library |
| issn | 1776-1042 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj-art-e9f76f07a31544609735ff958d7fc33a2025-07-04T09:35:36ZengEDP SciencesParasite1776-10422025-01-01324010.1051/parasite/2025036parasite240173Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central AfricaObame-Nkoghe Judicaël0https://orcid.org/0000-0003-4301-7745Kondji Faël Moudoumi1Diouf El Hadji2Thiaw Omar3Niangui Brad Ghaven4Ondo-Oyono Arnauld5Okomo-Nguema Yasmine6Longo-Pendy Neil Michel7Mounioko Franck8Makanga Boris9Kamgang Basile10Paupy Christophe11Kengne Pierre12Otomo Patricks Voua13Niang El Hadji Amadou14Département de Biologie de l’Université des Sciences et Techniques de Masuku (USTM)Département de Biologie de l’Université des Sciences et Techniques de Masuku (USTM)Laboratoire d’Écologie Vectorielle et Parasitaire, Université Cheikh Anta Diop de DakarLaboratoire d’Écologie Vectorielle et Parasitaire, Université Cheikh Anta Diop de DakarDépartement de Biologie de l’Université des Sciences et Techniques de Masuku (USTM)Unité de Recherche en Ecologie de la Santé du Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF)Unité de Recherche en Ecologie de la Santé du Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF)Unité de Recherche en Ecologie de la Santé du Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF)Département de Biologie de l’Université des Sciences et Techniques de Masuku (USTM)Research Institute in Tropical Ecology (IRET)Centre for Research in Infectious Diseases (CRID)MIVEGEC, Univ. Montpellier, CNRS, IRDMIVEGEC, Univ. Montpellier, CNRS, IRDDepartment of Zoology and Entomology, Faculty of Natural and Agricultural Sciences, University of the Free StateLaboratoire d’Écologie Vectorielle et Parasitaire, Université Cheikh Anta Diop de DakarThe spread of resistance to insecticides, such as pyrethroids, in Aedes vectors increases the risk of spread of arboviral diseases. In Gabon, the insecticide resistance profiles of Ae. aegypti and Ae. albopictus species remain poorly known. During a study to monitor the dynamics of Aedes populations in Franceville, in south-east Gabon, the resistance profiles of these two species to pyrethroids, organophosphates and carbamates were assessed. Susceptibility tests on adults and synergist tests with piperonyl butoxide (PBO) were carried out as per the World Health Organization protocol. The results showed that Ae. aegypti and Ae. albopictus were susceptible to permethrin, pirimiphos-methyl and bendiocarb. However, both species were resistant to deltamethrin (mortality: 67% for Ae. aegypti; 33% for Ae. albopictus). Exposure to a 5-fold dose of deltamethrin increased mortality to 100% and 91% for Ae. aegypti and Ae. albopictus, respectively. Resistance to alpha-cypermethrin was also recorded (mortality: 82% for Ae. aegypti; 64.6% for Ae. albopictus). Pre-exposure to PBO resulted in the restoration of susceptibility to deltamethrin and alpha-cypermethrin for Ae. aegypti, and a significant increase in mortality for Ae. albopictus. These data provide the first evidence of pyrethroid resistance in Aedes in Gabon and could help to establish more effective control measures against arbovirus vectors.https://www.parasite-journal.org/articles/parasite/full_html/2025/01/parasite240173/parasite240173.htmlaedesinsecticide resistancepyrethroidsorganophosphatescarbamatespbo |
| spellingShingle | Obame-Nkoghe Judicaël Kondji Faël Moudoumi Diouf El Hadji Thiaw Omar Niangui Brad Ghaven Ondo-Oyono Arnauld Okomo-Nguema Yasmine Longo-Pendy Neil Michel Mounioko Franck Makanga Boris Kamgang Basile Paupy Christophe Kengne Pierre Otomo Patricks Voua Niang El Hadji Amadou Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa Parasite aedes insecticide resistance pyrethroids organophosphates carbamates pbo |
| title | Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa |
| title_full | Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa |
| title_fullStr | Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa |
| title_full_unstemmed | Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa |
| title_short | Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa |
| title_sort | bioassay tests reveal for the first time pyrethroid resistance in aedes mosquitoes from franceville southeast gabon central africa |
| topic | aedes insecticide resistance pyrethroids organophosphates carbamates pbo |
| url | https://www.parasite-journal.org/articles/parasite/full_html/2025/01/parasite240173/parasite240173.html |
| work_keys_str_mv | AT obamenkoghejudicael bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT kondjifaelmoudoumi bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT dioufelhadji bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT thiawomar bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT nianguibradghaven bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT ondooyonoarnauld bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT okomonguemayasmine bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT longopendyneilmichel bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT mouniokofranck bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT makangaboris bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT kamgangbasile bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT paupychristophe bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT kengnepierre bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT otomopatricksvoua bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica AT niangelhadjiamadou bioassaytestsrevealforthefirsttimepyrethroidresistanceinaedesmosquitoesfromfrancevillesoutheastgaboncentralafrica |