Local excision±chemoradiotherapy vs.to tal mesorectal excision for early rectal cancer:case-matched analysis of long-term results
[Background] Our aim was to compare the bowel function and oncologic outcomes following these two treatment modalities. [Materials and methods] This was a single-center study with 67 patients included between 2009 and 2018. A total of 32 patients underwent total mesorectal excision (TME) group and 3...
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| Tác giả chính: | |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | Tiếng Trung |
| Được phát hành: |
Editorial Office of Journal of Colorectal & Anal Surgery
2022-02-01
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| Loạt: | 结直肠肛门外科 |
| Truy cập trực tuyến: | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=468&cateName=2022%E5%B9%B4%20%E7%AC%AC28%E5%8D%B7%20%E7%AC%AC1%E6%9C%9F |
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| Tóm tắt: | [Background] Our aim was to compare the bowel function and oncologic outcomes following these two treatment modalities. [Materials and methods] This was a single-center study with 67 patients included between 2009 and 2018. A total of 32 patients underwent total mesorectal excision (TME) group and 35 transanal local excisions (LE) ± chemoradiation. We performed a case-matched analysis: we matched the patients by age, cancer stage, and comorbidities. Duration of operation, postoperative complications, length of hospital stay, and long-term functional and oncological outcomes were compared. We calculated oncological outcomes using Kaplan-Meier Cox diagrams. In addition, we used a low anterior resection syndrome (LARS) score for the bowel function assessment. [Results] Mean operation time in the LE group was 58.8 ± 45 min compared with the TME group that was 121.1 ± 42 min (p=0.032). Complications were seen in 5.7% in LE group and 15.62% in TME group (p=0.043). ～85.2% of the patients had no LARS in LE group compared with 54.5% in TME group (p=0.018). Minor LARS was 7.4% in LE group compared with 31.8% in TME group (p=0.018); major LARS was 7.4 and 13.7%, respectively (p=0.474). Hospital stay was 2.77 days in LE group compared with 9.21 days in TME group (p=0.036). The overall survival was 68.78 months in LE group compared with 74.81 months in TME group (p=0.964). [Conclusion] Our results of a small sample size showed that local excision ± chemoradiation is a rather safe method for early rectal cancer compared with gold standard treatment. In addition, better bowel function is preserved with less postoperative complications and shorter hospital stays. |
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| số ISSN: | 1674-0491 |