Clinical value of dynamic testing of viral load level in blood at patients with natural course of chronic HBV-monoinfection
Aim of investigation. To determine clinical value of viral load level (VLL) of HBV in blood at patients with natural course of chronic HBV-monoinfection.Material and methods. Overall 149 patients were investigated. Of them 68 (45,6%) were women and 81 man (54,4%) in the age of 16 to 71 years. Molecu...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2009-12-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1754 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839586585072369664 |
|---|---|
| author | S. A. Shutko K. R. Dudina O. O. Znoyko Ye. A. Klimova V. I. Kashirin D. S. Cheshik N. D. Yushchuk |
| author_facet | S. A. Shutko K. R. Dudina O. O. Znoyko Ye. A. Klimova V. I. Kashirin D. S. Cheshik N. D. Yushchuk |
| author_sort | S. A. Shutko |
| collection | DOAJ |
| description | Aim of investigation. To determine clinical value of viral load level (VLL) of HBV in blood at patients with natural course of chronic HBV-monoinfection.Material and methods. Overall 149 patients were investigated. Of them 68 (45,6%) were women and 81 man (54,4%) in the age of 16 to 71 years. Molecularbiological analysis for the presence of hepatitis B virus DNA in blood was carried out three times with 6 months intervals by polymerase chain reaction (PCR) method in a «real time» mode (test-sensitivity 103 copies/ml).Results. At triple complex investigation 20% of HBsAg inactive carriers have been selected. At a single PCR – test at the majority (59,5%) of patients with chronic hepatitis B (CHB) no HBV DNA was determined in a blood, while at two-times and triple study the number of patients with not determined HBV DNA level reduced apparently (41 and 12,5% respectively). Analysis has indicated, that CHB patients have direct correlation between alanine transaminases (ALT) activity and HBV DNA VLL (r=0,385, р=0,008). Only in 9% of cases constantly high VLL was registered, mainly, on a background of elevated activity of ALT. The progressing form of CHB has been diagnosed in 21,7% of patients with natural course of chronic HBV-monoinfection for this they have been recognized as candidates for antiviral therapy.Conclusions. In original study the direct correlation between parameters of HBV VLL and ALT activity at patients with natural course of chronic HBV-monoinfection was revealed. Only complex dynamic assessment of such patients helps to define absolute candidates for prescription of antiviral therapy and to determine proportion of inactive HBsAg carriers. |
| format | Article |
| id | doaj-art-e9de4d23d12f4c22b508577ebfbd73e5 |
| institution | Matheson Library |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2009-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-e9de4d23d12f4c22b508577ebfbd73e52025-08-03T19:25:28ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732009-12-0119628331185Clinical value of dynamic testing of viral load level in blood at patients with natural course of chronic HBV-monoinfectionS. A. ShutkoK. R. DudinaO. O. ZnoykoYe. A. KlimovaV. I. KashirinD. S. CheshikN. D. YushchukAim of investigation. To determine clinical value of viral load level (VLL) of HBV in blood at patients with natural course of chronic HBV-monoinfection.Material and methods. Overall 149 patients were investigated. Of them 68 (45,6%) were women and 81 man (54,4%) in the age of 16 to 71 years. Molecularbiological analysis for the presence of hepatitis B virus DNA in blood was carried out three times with 6 months intervals by polymerase chain reaction (PCR) method in a «real time» mode (test-sensitivity 103 copies/ml).Results. At triple complex investigation 20% of HBsAg inactive carriers have been selected. At a single PCR – test at the majority (59,5%) of patients with chronic hepatitis B (CHB) no HBV DNA was determined in a blood, while at two-times and triple study the number of patients with not determined HBV DNA level reduced apparently (41 and 12,5% respectively). Analysis has indicated, that CHB patients have direct correlation between alanine transaminases (ALT) activity and HBV DNA VLL (r=0,385, р=0,008). Only in 9% of cases constantly high VLL was registered, mainly, on a background of elevated activity of ALT. The progressing form of CHB has been diagnosed in 21,7% of patients with natural course of chronic HBV-monoinfection for this they have been recognized as candidates for antiviral therapy.Conclusions. In original study the direct correlation between parameters of HBV VLL and ALT activity at patients with natural course of chronic HBV-monoinfection was revealed. Only complex dynamic assessment of such patients helps to define absolute candidates for prescription of antiviral therapy and to determine proportion of inactive HBsAg carriers.https://www.gastro-j.ru/jour/article/view/1754hbv dna in bloodchronic hepatitis bviral load level |
| spellingShingle | S. A. Shutko K. R. Dudina O. O. Znoyko Ye. A. Klimova V. I. Kashirin D. S. Cheshik N. D. Yushchuk Clinical value of dynamic testing of viral load level in blood at patients with natural course of chronic HBV-monoinfection Российский журнал гастроэнтерологии, гепатологии, колопроктологии hbv dna in blood chronic hepatitis b viral load level |
| title | Clinical value of dynamic testing of viral load level in blood at patients with natural course of chronic HBV-monoinfection |
| title_full | Clinical value of dynamic testing of viral load level in blood at patients with natural course of chronic HBV-monoinfection |
| title_fullStr | Clinical value of dynamic testing of viral load level in blood at patients with natural course of chronic HBV-monoinfection |
| title_full_unstemmed | Clinical value of dynamic testing of viral load level in blood at patients with natural course of chronic HBV-monoinfection |
| title_short | Clinical value of dynamic testing of viral load level in blood at patients with natural course of chronic HBV-monoinfection |
| title_sort | clinical value of dynamic testing of viral load level in blood at patients with natural course of chronic hbv monoinfection |
| topic | hbv dna in blood chronic hepatitis b viral load level |
| url | https://www.gastro-j.ru/jour/article/view/1754 |
| work_keys_str_mv | AT sashutko clinicalvalueofdynamictestingofviralloadlevelinbloodatpatientswithnaturalcourseofchronichbvmonoinfection AT krdudina clinicalvalueofdynamictestingofviralloadlevelinbloodatpatientswithnaturalcourseofchronichbvmonoinfection AT ooznoyko clinicalvalueofdynamictestingofviralloadlevelinbloodatpatientswithnaturalcourseofchronichbvmonoinfection AT yeaklimova clinicalvalueofdynamictestingofviralloadlevelinbloodatpatientswithnaturalcourseofchronichbvmonoinfection AT vikashirin clinicalvalueofdynamictestingofviralloadlevelinbloodatpatientswithnaturalcourseofchronichbvmonoinfection AT dscheshik clinicalvalueofdynamictestingofviralloadlevelinbloodatpatientswithnaturalcourseofchronichbvmonoinfection AT ndyushchuk clinicalvalueofdynamictestingofviralloadlevelinbloodatpatientswithnaturalcourseofchronichbvmonoinfection |