Unraveling the aging-reversal potency of stem cell-derived extracellular vesicles in a rat model of premature cardiac senescence

Unraveling the aging-reversal potency of stem cell-derived extracellular vesicles in a rat model of premature cardiac senescence

Summary: Cardiosphere-derived cells (CDCs) and their extracellular vesicles (CDC-EVs) can rejuvenate and improve cardiac function, but their efficacy varies among donors. This study aimed to identify predictors of CDC-EV potency. CDCs from human donors were analyzed for phenotypical and biological p...

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Main Authors: Lidia Gómez-Cid, Alexia Campo-Fonseca, Mar Cervera-Negueruela, Alejandra Ocampo, Ángel Pinto, Juan Miguel Gil-Jaurena, Susana Suárez-Sancho, Francisco Fernández-Avilés, Lilian Grigorian-Shamagian
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Biological sciences
Cell biology
Biological sciences research methodologies
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422501171X
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