Short-chain fatty acids: key antiviral mediators of gut microbiota
The effects of gut microbiota on antiviral immunity have been well-documented in recent years, whereas a mechanistic understanding of microbiota-derived metabolite-related signaling pathways is still lacking. Short-chain fatty acids (SCFAs), key metabolites produced by gut bacterial microbiota via d...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1614879/full |
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| _version_ | 1839617081104924672 |
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| author | Zhiqiang Xu Tao Wang Yanjin Wang Yongfeng Li Yuan Sun Hua-Ji Qiu |
| author_facet | Zhiqiang Xu Tao Wang Yanjin Wang Yongfeng Li Yuan Sun Hua-Ji Qiu |
| author_sort | Zhiqiang Xu |
| collection | DOAJ |
| description | The effects of gut microbiota on antiviral immunity have been well-documented in recent years, whereas a mechanistic understanding of microbiota-derived metabolite-related signaling pathways is still lacking. Short-chain fatty acids (SCFAs), key metabolites produced by gut bacterial microbiota via dietary fiber fermentation and amino acid metabolism, have been shown to facilitate host antiviral responses. In this review, we summarized the detailed mechanisms which could contribute to the regulation of antiviral immunity engaged and initiated by SCFAs, involving G-protein-coupled receptor (GPCR)-mediated, histone deacetylase (HDAC)-mediated, and metabolic pathways. We also discuss the implications of SCFAs for viral disease management and pandemic preparedness. This review provides novel insights into the antiviral activities of SCFAs and highlights the therapeutic potential of SCFA-producing bacteria. |
| format | Article |
| id | doaj-art-e9729d1b93444f16b1e7a5a85d4f5ab0 |
| institution | Matheson Library |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e9729d1b93444f16b1e7a5a85d4f5ab02025-07-25T06:17:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.16148791614879Short-chain fatty acids: key antiviral mediators of gut microbiotaZhiqiang XuTao WangYanjin WangYongfeng LiYuan SunHua-Ji QiuThe effects of gut microbiota on antiviral immunity have been well-documented in recent years, whereas a mechanistic understanding of microbiota-derived metabolite-related signaling pathways is still lacking. Short-chain fatty acids (SCFAs), key metabolites produced by gut bacterial microbiota via dietary fiber fermentation and amino acid metabolism, have been shown to facilitate host antiviral responses. In this review, we summarized the detailed mechanisms which could contribute to the regulation of antiviral immunity engaged and initiated by SCFAs, involving G-protein-coupled receptor (GPCR)-mediated, histone deacetylase (HDAC)-mediated, and metabolic pathways. We also discuss the implications of SCFAs for viral disease management and pandemic preparedness. This review provides novel insights into the antiviral activities of SCFAs and highlights the therapeutic potential of SCFA-producing bacteria.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1614879/fullantiviral immunityG-protein-coupled receptorgut microbiotahistone acetyltransferasehistone deacetylaseshort-chain fatty acid |
| spellingShingle | Zhiqiang Xu Tao Wang Yanjin Wang Yongfeng Li Yuan Sun Hua-Ji Qiu Short-chain fatty acids: key antiviral mediators of gut microbiota Frontiers in Immunology antiviral immunity G-protein-coupled receptor gut microbiota histone acetyltransferase histone deacetylase short-chain fatty acid |
| title | Short-chain fatty acids: key antiviral mediators of gut microbiota |
| title_full | Short-chain fatty acids: key antiviral mediators of gut microbiota |
| title_fullStr | Short-chain fatty acids: key antiviral mediators of gut microbiota |
| title_full_unstemmed | Short-chain fatty acids: key antiviral mediators of gut microbiota |
| title_short | Short-chain fatty acids: key antiviral mediators of gut microbiota |
| title_sort | short chain fatty acids key antiviral mediators of gut microbiota |
| topic | antiviral immunity G-protein-coupled receptor gut microbiota histone acetyltransferase histone deacetylase short-chain fatty acid |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1614879/full |
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