Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England
Shigellosis is a bacterial infection that causes enteric illness and can be sexually transmitted, particularly among gay, bisexual, and other men who have sex with men. Multiple extensively drug-resistant Shigella strains have been detected through genomic surveillance and are associated with plasm...
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| Formaat: | Artikel |
| Taal: | Engels |
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Centers for Disease Control and Prevention
2025-07-01
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| Reeks: | Emerging Infectious Diseases |
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| Online toegang: | https://wwwnc.cdc.gov/eid/article/31/7/24-1584_article |
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| _version_ | 1839652362236461056 |
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| author | Hannah Charles David R. Greig Craig Swift Israel Olonade Ian Simms Katy Sinka Kate S. Baker Gauri Godbole Claire Jenkins |
| author_facet | Hannah Charles David R. Greig Craig Swift Israel Olonade Ian Simms Katy Sinka Kate S. Baker Gauri Godbole Claire Jenkins |
| author_sort | Hannah Charles |
| collection | DOAJ |
| description |
Shigellosis is a bacterial infection that causes enteric illness and can be sexually transmitted, particularly among gay, bisexual, and other men who have sex with men. Multiple extensively drug-resistant Shigella strains have been detected through genomic surveillance and are associated with plasmids carrying the gene variant blaCTX-M-27 in the United Kingdom. We report an increase in possible sexually transmitted cases of Shigella bacteria carrying the blaCTX-M-15 gene variant, which was previously associated with travel. In 2023, there were 117 cases belonging to the 10 single-nucleotide polymorphism linkage cluster t10.1814. Although this cluster has been documented in England since August 2019, genetic analyses revealed that the blaCTX-M-15 gene variant entered the lineage on a novel resistance plasmid coinciding with the first outbreak case. Our analysis highlights the shifting antimicrobial resistance landscape of sexually transmitted Shigella bacteria. Parallel emergence of resistance determinants against third-generation cephalosporins in sexual transmission networks suggests high levels of antimicrobial selection pressure.
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| format | Article |
| id | doaj-art-e899b161e2b64d8ca7e8c820bd5129d2 |
| institution | Matheson Library |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-e899b161e2b64d8ca7e8c820bd5129d22025-06-25T14:59:23ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-07-013171394140510.3201/eid3107.241584Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, EnglandHannah CharlesDavid R. GreigCraig SwiftIsrael OlonadeIan SimmsKaty SinkaKate S. BakerGauri GodboleClaire Jenkins Shigellosis is a bacterial infection that causes enteric illness and can be sexually transmitted, particularly among gay, bisexual, and other men who have sex with men. Multiple extensively drug-resistant Shigella strains have been detected through genomic surveillance and are associated with plasmids carrying the gene variant blaCTX-M-27 in the United Kingdom. We report an increase in possible sexually transmitted cases of Shigella bacteria carrying the blaCTX-M-15 gene variant, which was previously associated with travel. In 2023, there were 117 cases belonging to the 10 single-nucleotide polymorphism linkage cluster t10.1814. Although this cluster has been documented in England since August 2019, genetic analyses revealed that the blaCTX-M-15 gene variant entered the lineage on a novel resistance plasmid coinciding with the first outbreak case. Our analysis highlights the shifting antimicrobial resistance landscape of sexually transmitted Shigella bacteria. Parallel emergence of resistance determinants against third-generation cephalosporins in sexual transmission networks suggests high levels of antimicrobial selection pressure. https://wwwnc.cdc.gov/eid/article/31/7/24-1584_articleShigellaS. sonneiS. sonnei blaCTXM-15sexually transmitted infectionsantimicrobial resistanceenteric infections |
| spellingShingle | Hannah Charles David R. Greig Craig Swift Israel Olonade Ian Simms Katy Sinka Kate S. Baker Gauri Godbole Claire Jenkins Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England Emerging Infectious Diseases Shigella S. sonnei S. sonnei blaCTXM-15 sexually transmitted infections antimicrobial resistance enteric infections |
| title | Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England |
| title_full | Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England |
| title_fullStr | Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England |
| title_full_unstemmed | Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England |
| title_short | Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England |
| title_sort | epidemiologic and genomic investigation of sexually transmitted shigella sonnei england |
| topic | Shigella S. sonnei S. sonnei blaCTXM-15 sexually transmitted infections antimicrobial resistance enteric infections |
| url | https://wwwnc.cdc.gov/eid/article/31/7/24-1584_article |
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