Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England
Shigellosis is a bacterial infection that causes enteric illness and can be sexually transmitted, particularly among gay, bisexual, and other men who have sex with men. Multiple extensively drug-resistant Shigella strains have been detected through genomic surveillance and are associated with plasm...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2025-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/31/7/24-1584_article |
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| Summary: | Shigellosis is a bacterial infection that causes enteric illness and can be sexually transmitted, particularly among gay, bisexual, and other men who have sex with men. Multiple extensively drug-resistant Shigella strains have been detected through genomic surveillance and are associated with plasmids carrying the gene variant blaCTX-M-27 in the United Kingdom. We report an increase in possible sexually transmitted cases of Shigella bacteria carrying the blaCTX-M-15 gene variant, which was previously associated with travel. In 2023, there were 117 cases belonging to the 10 single-nucleotide polymorphism linkage cluster t10.1814. Although this cluster has been documented in England since August 2019, genetic analyses revealed that the blaCTX-M-15 gene variant entered the lineage on a novel resistance plasmid coinciding with the first outbreak case. Our analysis highlights the shifting antimicrobial resistance landscape of sexually transmitted Shigella bacteria. Parallel emergence of resistance determinants against third-generation cephalosporins in sexual transmission networks suggests high levels of antimicrobial selection pressure.
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| ISSN: | 1080-6040 1080-6059 |