Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1

Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1

A major obstacle in type 2 diabetes mellitus (T2DM) is sleep fragmentation (SF), which negatively affects testicular function. However, the underlying mechanisms remain to be elucidated. In this study, we demonstrate that SF induces testicular damage through a mechanism involving lipid metabolism, s...

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Bibliographic Details
Main Authors: Xiaohui Zhang, Xinyu Tang, Ting Gao, Yuanfang Guo, Guangping Lu, Qingbo Liu, Jiahao Li, Jie Wang, Mingrui Liu, Dongmei Zhang, Yufeng Tang, Junlian Gu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Sleep fragmentation
Testicular injury
Melatonin receptor
Lipid metabolism
FGFR1
TAB1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525003247
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