Protective Effects of N-Acetylcysteine in Alleviating Cocaine-Mediated Microglial Activation and Neuroinflammation

Protective Effects of N-Acetylcysteine in Alleviating Cocaine-Mediated Microglial Activation and Neuroinflammation

Cocaine misuse induces microglial activation and neuroinflammation, contributing to neurodegeneration and behavioral impairments. Prior studies have shown that cocaine induces mitochondrial dysfunction, dysregulated mitophagy, and lysosomal impairment in microglia. Here, we investigated the therapeu...

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Bibliographic Details
Main Authors: Uma Maheswari Deshetty, Abiola Oladapo, Yazhini Mohankumar, Elias Horanieh, Shilpa Buch, Palsamy Periyasamy
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biology
Subjects:
cocaine
neuroinflammation
microglial activation
N-acetylcysteine
mitophagy
autophagy
Online Access:https://www.mdpi.com/2079-7737/14/7/893
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