Rapid suppression of HBV replication before related liver transplantation in a patient with HDV superinfection. Clinical case report
Chronic hepatitis B virus (HBV) infection is one of the main problems of modern transplantology and transplant hepatology, often leading to potentially fatal complications. The only definitive treatment for HBV-related cirrhosis is liver transplantation. However, recurrence of HBV after transplantat...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2024-09-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/1785 |
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| author | U. R. Salimov P. Balachandran D. B. Tulyaganov M. R. Ruzibakieva F. A. Khadjibaev K. E. Anvarov |
| author_facet | U. R. Salimov P. Balachandran D. B. Tulyaganov M. R. Ruzibakieva F. A. Khadjibaev K. E. Anvarov |
| author_sort | U. R. Salimov |
| collection | DOAJ |
| description | Chronic hepatitis B virus (HBV) infection is one of the main problems of modern transplantology and transplant hepatology, often leading to potentially fatal complications. The only definitive treatment for HBV-related cirrhosis is liver transplantation. However, recurrence of HBV after transplantation may jeopardize both recipient and graft survival. Therefore, all HBsAg-positive recipients should receive prophylactic therapy with nucleos(t)ide analogues with or without hepatitis B immune globulin (HBIG), regardless of the hepatitis B e-antigen (HBeAg) status and HBV DNA level before transplantation. However, HBIG therapy has a number of disadvantages, and nucleos(t) ide analogues do not inhibit replication of super and co-infection. In addition, there is no unified understanding of the time limits for achieving a virologic response. In our clinical case, we report a rapid suppression (5 days) of high HBV (560,000 copies/mL) viral load in a patient suffering from HBV- and HDV-related cirrhosis, who was operated on with positive HBeAg at the time of transplantation. In our study, the use of standard therapy tenofovir disoproxil fumarate reduced the HBV viral load titer to undetectable values. In turn, given the positiveHBeAg at the time of transplantation, HBV infection recurred in the early post-transplant period, which was eliminated without the use of HBIG therapy. The use of tenofovir disoproxil fumarate makes it possible to plan transplantation for patients with positive replication and high viral load, avoiding the use of HBIG, against the background of limited liver transplant wait time. |
| format | Article |
| id | doaj-art-e7f83c1bf9184c68aaa58c4398e5d005 |
| institution | Matheson Library |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2024-09-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-e7f83c1bf9184c68aaa58c4398e5d0052025-08-04T14:02:12ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912024-09-01263667110.15825/10.15825/1995-1191-2024-3-66-711273Rapid suppression of HBV replication before related liver transplantation in a patient with HDV superinfection. Clinical case reportU. R. Salimov0P. Balachandran1D. B. Tulyaganov2M. R. Ruzibakieva3F. A. Khadjibaev4K. E. Anvarov5Republican Research Center for Emergency MedicineAsian Institute of GastroenterologyRepublican Research Center for Emergency MedicineInstitute of Immunology and Human GenomicsRepublican Research Center for Emergency MedicineRepublican Research Center for Emergency MedicineChronic hepatitis B virus (HBV) infection is one of the main problems of modern transplantology and transplant hepatology, often leading to potentially fatal complications. The only definitive treatment for HBV-related cirrhosis is liver transplantation. However, recurrence of HBV after transplantation may jeopardize both recipient and graft survival. Therefore, all HBsAg-positive recipients should receive prophylactic therapy with nucleos(t)ide analogues with or without hepatitis B immune globulin (HBIG), regardless of the hepatitis B e-antigen (HBeAg) status and HBV DNA level before transplantation. However, HBIG therapy has a number of disadvantages, and nucleos(t) ide analogues do not inhibit replication of super and co-infection. In addition, there is no unified understanding of the time limits for achieving a virologic response. In our clinical case, we report a rapid suppression (5 days) of high HBV (560,000 copies/mL) viral load in a patient suffering from HBV- and HDV-related cirrhosis, who was operated on with positive HBeAg at the time of transplantation. In our study, the use of standard therapy tenofovir disoproxil fumarate reduced the HBV viral load titer to undetectable values. In turn, given the positiveHBeAg at the time of transplantation, HBV infection recurred in the early post-transplant period, which was eliminated without the use of HBIG therapy. The use of tenofovir disoproxil fumarate makes it possible to plan transplantation for patients with positive replication and high viral load, avoiding the use of HBIG, against the background of limited liver transplant wait time.https://journal.transpl.ru/vtio/article/view/1785liver transplantationhepatitis bhepatitis dtenofovir disoproxil fumaratetenofovir alafenamidenucleos(t)ide analogues |
| spellingShingle | U. R. Salimov P. Balachandran D. B. Tulyaganov M. R. Ruzibakieva F. A. Khadjibaev K. E. Anvarov Rapid suppression of HBV replication before related liver transplantation in a patient with HDV superinfection. Clinical case report Вестник трансплантологии и искусственных органов liver transplantation hepatitis b hepatitis d tenofovir disoproxil fumarate tenofovir alafenamide nucleos(t)ide analogues |
| title | Rapid suppression of HBV replication before related liver transplantation in a patient with HDV superinfection. Clinical case report |
| title_full | Rapid suppression of HBV replication before related liver transplantation in a patient with HDV superinfection. Clinical case report |
| title_fullStr | Rapid suppression of HBV replication before related liver transplantation in a patient with HDV superinfection. Clinical case report |
| title_full_unstemmed | Rapid suppression of HBV replication before related liver transplantation in a patient with HDV superinfection. Clinical case report |
| title_short | Rapid suppression of HBV replication before related liver transplantation in a patient with HDV superinfection. Clinical case report |
| title_sort | rapid suppression of hbv replication before related liver transplantation in a patient with hdv superinfection clinical case report |
| topic | liver transplantation hepatitis b hepatitis d tenofovir disoproxil fumarate tenofovir alafenamide nucleos(t)ide analogues |
| url | https://journal.transpl.ru/vtio/article/view/1785 |
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