Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter?
Stereotactic radiosurgery (SRS) deploys image-guidance to deliver multiple beams of highly focused ionizing radiation to tightly conformed anatomical targets, leading to precise dosing of radiation-induced cellular injury and predictable biological responses that can be applied to treat a multitude...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/15/6/649 |
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| author | Fred C. Lam John Byun Santosh Guru Deyaldeen AbuReesh Yusuke S. Hori Elham Rahimy Erqi Liu Pollom Scott Soltys David J. Park Steven D. Chang |
| author_facet | Fred C. Lam John Byun Santosh Guru Deyaldeen AbuReesh Yusuke S. Hori Elham Rahimy Erqi Liu Pollom Scott Soltys David J. Park Steven D. Chang |
| author_sort | Fred C. Lam |
| collection | DOAJ |
| description | Stereotactic radiosurgery (SRS) deploys image-guidance to deliver multiple beams of highly focused ionizing radiation to tightly conformed anatomical targets, leading to precise dosing of radiation-induced cellular injury and predictable biological responses that can be applied to treat a multitude of central nervous system (CNS) disorders. Herein we review the principles of CNS radiobiology, comparing differences between SRS and conventional radiation therapy. We then review the radiobiology of SRS as it pertains to the treatment of CNS tumors and vascular malformations and the emerging application of SRS for the treatment of functional and psychiatric neurological disorders. Finally, we look toward the future in combining SRS with other novel technologies to improve treatment outcomes for patients with CNS disorders. |
| format | Article |
| id | doaj-art-e7f2b8ebc2084adf8edfe1729a32c95d |
| institution | Matheson Library |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-e7f2b8ebc2084adf8edfe1729a32c95d2025-06-25T13:35:27ZengMDPI AGBrain Sciences2076-34252025-06-0115664910.3390/brainsci15060649Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter?Fred C. Lam0John Byun1Santosh Guru2Deyaldeen AbuReesh3Yusuke S. Hori4Elham Rahimy5Erqi Liu Pollom6Scott Soltys7David J. Park8Steven D. Chang9Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USADepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USADepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USADepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USADepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USADepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USAStereotactic radiosurgery (SRS) deploys image-guidance to deliver multiple beams of highly focused ionizing radiation to tightly conformed anatomical targets, leading to precise dosing of radiation-induced cellular injury and predictable biological responses that can be applied to treat a multitude of central nervous system (CNS) disorders. Herein we review the principles of CNS radiobiology, comparing differences between SRS and conventional radiation therapy. We then review the radiobiology of SRS as it pertains to the treatment of CNS tumors and vascular malformations and the emerging application of SRS for the treatment of functional and psychiatric neurological disorders. Finally, we look toward the future in combining SRS with other novel technologies to improve treatment outcomes for patients with CNS disorders.https://www.mdpi.com/2076-3425/15/6/649stereotactic radiosurgeryCyberknifeGammaknifeproton beam radiation therapyconventional radiotherapyneurosurgery |
| spellingShingle | Fred C. Lam John Byun Santosh Guru Deyaldeen AbuReesh Yusuke S. Hori Elham Rahimy Erqi Liu Pollom Scott Soltys David J. Park Steven D. Chang Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter? Brain Sciences stereotactic radiosurgery Cyberknife Gammaknife proton beam radiation therapy conventional radiotherapy neurosurgery |
| title | Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter? |
| title_full | Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter? |
| title_fullStr | Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter? |
| title_full_unstemmed | Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter? |
| title_short | Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter? |
| title_sort | understanding the radiobiology of central nervous system diseases in the golden age of radiosurgery does it matter |
| topic | stereotactic radiosurgery Cyberknife Gammaknife proton beam radiation therapy conventional radiotherapy neurosurgery |
| url | https://www.mdpi.com/2076-3425/15/6/649 |
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