Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter?

Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter?

Stereotactic radiosurgery (SRS) deploys image-guidance to deliver multiple beams of highly focused ionizing radiation to tightly conformed anatomical targets, leading to precise dosing of radiation-induced cellular injury and predictable biological responses that can be applied to treat a multitude...

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Bibliographic Details
Main Authors: Fred C. Lam, John Byun, Santosh Guru, Deyaldeen AbuReesh, Yusuke S. Hori, Elham Rahimy, Erqi Liu Pollom, Scott Soltys, David J. Park, Steven D. Chang
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Brain Sciences
Subjects:
stereotactic radiosurgery
Cyberknife
Gammaknife
proton beam radiation therapy
conventional radiotherapy
neurosurgery
Online Access:https://www.mdpi.com/2076-3425/15/6/649
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Summary:Stereotactic radiosurgery (SRS) deploys image-guidance to deliver multiple beams of highly focused ionizing radiation to tightly conformed anatomical targets, leading to precise dosing of radiation-induced cellular injury and predictable biological responses that can be applied to treat a multitude of central nervous system (CNS) disorders. Herein we review the principles of CNS radiobiology, comparing differences between SRS and conventional radiation therapy. We then review the radiobiology of SRS as it pertains to the treatment of CNS tumors and vascular malformations and the emerging application of SRS for the treatment of functional and psychiatric neurological disorders. Finally, we look toward the future in combining SRS with other novel technologies to improve treatment outcomes for patients with CNS disorders.
ISSN:2076-3425

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