Sedentary behavior, cognition, and brain health in older adults: a systematic review
Sedentary behavior has been associated with poor health outcomes, especially in older adulthood. Given that sedentary behavior is a highly prevalent, modifiable health behavior, there has been a recent increased interest in examining how sedentary behavior relates to cognition and brain health. The...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1622049/full |
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| author | Marissa A. Gogniat Junyeon Won Junyeon Won Carlos Cruz Carlos Cruz Amaya Aranda Aryan Verma Swathi Gujral Andrea M. Weinstein Afsara B. Zaheed Keith R. Cole Keith R. Cole Kelsie M. Full Kelsie M. Full Beth E. Snitz |
| author_facet | Marissa A. Gogniat Junyeon Won Junyeon Won Carlos Cruz Carlos Cruz Amaya Aranda Aryan Verma Swathi Gujral Andrea M. Weinstein Afsara B. Zaheed Keith R. Cole Keith R. Cole Kelsie M. Full Kelsie M. Full Beth E. Snitz |
| author_sort | Marissa A. Gogniat |
| collection | DOAJ |
| description | Sedentary behavior has been associated with poor health outcomes, especially in older adulthood. Given that sedentary behavior is a highly prevalent, modifiable health behavior, there has been a recent increased interest in examining how sedentary behavior relates to cognition and brain health. The current body of literature is limited and mixed. The purpose of this systematic review was to examine the associations of sedentary behavior with cognition and brain health in older adults across the cognitive spectrum. This study was pre-registered with PROSPERO (CRD42023477868). Six comprehensive databases were searched with pre-registered search terms. A total of 33 studies were included. Overall, results indicated that greater sedentary behavior was associated with worse cognition and brain health, although associations varied based on differences in measurement and classification of sedentary behavior. We discuss next steps and implications for future research. |
| format | Article |
| id | doaj-art-e7d05f2a13ed46e994777d51a2db97d1 |
| institution | Matheson Library |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-e7d05f2a13ed46e994777d51a2db97d12025-07-08T05:26:34ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-07-011710.3389/fnagi.2025.16220491622049Sedentary behavior, cognition, and brain health in older adults: a systematic reviewMarissa A. Gogniat0Junyeon Won1Junyeon Won2Carlos Cruz3Carlos Cruz4Amaya Aranda5Aryan Verma6Swathi Gujral7Andrea M. Weinstein8Afsara B. Zaheed9Keith R. Cole10Keith R. Cole11Kelsie M. Full12Kelsie M. Full13Beth E. Snitz14Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United StatesDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United StatesInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United StatesDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, United StatesDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United StatesDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, United StatesVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, United StatesDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesSedentary behavior has been associated with poor health outcomes, especially in older adulthood. Given that sedentary behavior is a highly prevalent, modifiable health behavior, there has been a recent increased interest in examining how sedentary behavior relates to cognition and brain health. The current body of literature is limited and mixed. The purpose of this systematic review was to examine the associations of sedentary behavior with cognition and brain health in older adults across the cognitive spectrum. This study was pre-registered with PROSPERO (CRD42023477868). Six comprehensive databases were searched with pre-registered search terms. A total of 33 studies were included. Overall, results indicated that greater sedentary behavior was associated with worse cognition and brain health, although associations varied based on differences in measurement and classification of sedentary behavior. We discuss next steps and implications for future research.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1622049/fullsedentary behaviorcognitionAlzheimer’s diseasebrain healtholder adult |
| spellingShingle | Marissa A. Gogniat Junyeon Won Junyeon Won Carlos Cruz Carlos Cruz Amaya Aranda Aryan Verma Swathi Gujral Andrea M. Weinstein Afsara B. Zaheed Keith R. Cole Keith R. Cole Kelsie M. Full Kelsie M. Full Beth E. Snitz Sedentary behavior, cognition, and brain health in older adults: a systematic review Frontiers in Aging Neuroscience sedentary behavior cognition Alzheimer’s disease brain health older adult |
| title | Sedentary behavior, cognition, and brain health in older adults: a systematic review |
| title_full | Sedentary behavior, cognition, and brain health in older adults: a systematic review |
| title_fullStr | Sedentary behavior, cognition, and brain health in older adults: a systematic review |
| title_full_unstemmed | Sedentary behavior, cognition, and brain health in older adults: a systematic review |
| title_short | Sedentary behavior, cognition, and brain health in older adults: a systematic review |
| title_sort | sedentary behavior cognition and brain health in older adults a systematic review |
| topic | sedentary behavior cognition Alzheimer’s disease brain health older adult |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1622049/full |
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