Can K-ras gene mutation be utilized as prognostic biomarker for colorectal cancer patients receiving chemotherapy? A meta-analysis and systematic review.
<h4>Introduction</h4>K-ras gene mutations were common in colorectal patients, but their relationship with prognosis was unclear.<h4>Objective</h4>Verify prognostic differences between patient with and without mutant K-ras genes by reviewing the published evidence.<h4>Me...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0077901 |
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| Summary: | <h4>Introduction</h4>K-ras gene mutations were common in colorectal patients, but their relationship with prognosis was unclear.<h4>Objective</h4>Verify prognostic differences between patient with and without mutant K-ras genes by reviewing the published evidence.<h4>Method</h4>Systematic reviews and data bases were searched for cohort/case-control studies of prognosis of colorectal cancer patients with detected K-ras mutations versus those without mutant K-ras genes, both of whom received chemotherapy. Number of patients, regimens of chemotherapy, and short-term or long-term survival rate (disease-free or overall) were extracted. Quality of studies was also evaluated.<h4>Principal findings</h4>7 studies of comparisons with a control group were identified. No association between K-ras gene status with neither short-term disease free-survival (OR=1.01, 95% CI, 0.73-1.38, P=0.97) nor overall survival (OR=1.06, 95% CI, 0.82-1.36, P=0.66) in CRC patients who received chemotherapy was indicated. Comparison of long-term survival between two groups also indicated no significant difference after heterogeneity was eliminated (OR=1.09, 95% CI, 0.85-1.40, P=0.49).<h4>Conclusions</h4>K-ras gene mutations may not be a prognostic index for colorectal cancer patients who received chemotherapy. |
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| ISSN: | 1932-6203 |