Real-world efficacy of sublingual immunotherapy with Japanese cedar pollen for cypress pollinosis
Background: It remains unclear whether allergen immunotherapy with Japanese cedar pollen extract is effective for Japanese cypress pollinosis in real-world settings. Objective: We sought to investigate the Japan-wide prevalence of cypress pollinosis, the efficacy of cedar sublingual immunotherapy (S...
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Elsevier
2025-08-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325000645 |
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| author | Aiko Oka, MD Tamami Yamashita, MD Kengo Kanai, MD Atsushi Yuta, MD Yukiko Ogawa, MD Eriko Takahara, MD Hideki Shiratsuchi, MD Akihiko Terada, MD Takatsugu Tsunoda, MD Takeshi Masuda, MD Satoru Masuno, MD Kenichi Kanai, MD Hitoshi Nagakura, MD Reiko Tokuda, MD Harumi Arao, MD Hitoshi Bamba, MD Shigenobu Yasuda, MD Hideya Mimura, MD Mahoko Nakazato, MD Hidehisa Nakazato, MD Noriyuki Houya, MD Hideaki Tsuzuki, MD Masaharu Tokuriki, MD Mayuko Sakaida, MD Ryo Amesara, MD Chikahisa Ohkawa, MD Takemitsu Hama, MD Hiroki Ikeda, MD Hisaki Fukushima, MD Sumiko Niitsu, MD Hirofumi Sakaguchi, MD Norihito Iba, MD Hiroshi Kumanomidou, MD Yoshiyuki Hyo, MD Ryo Takagi, MD Takashi Koike, MD Marie Yamada, MD Mitsuhiro Okano, MD |
| author_facet | Aiko Oka, MD Tamami Yamashita, MD Kengo Kanai, MD Atsushi Yuta, MD Yukiko Ogawa, MD Eriko Takahara, MD Hideki Shiratsuchi, MD Akihiko Terada, MD Takatsugu Tsunoda, MD Takeshi Masuda, MD Satoru Masuno, MD Kenichi Kanai, MD Hitoshi Nagakura, MD Reiko Tokuda, MD Harumi Arao, MD Hitoshi Bamba, MD Shigenobu Yasuda, MD Hideya Mimura, MD Mahoko Nakazato, MD Hidehisa Nakazato, MD Noriyuki Houya, MD Hideaki Tsuzuki, MD Masaharu Tokuriki, MD Mayuko Sakaida, MD Ryo Amesara, MD Chikahisa Ohkawa, MD Takemitsu Hama, MD Hiroki Ikeda, MD Hisaki Fukushima, MD Sumiko Niitsu, MD Hirofumi Sakaguchi, MD Norihito Iba, MD Hiroshi Kumanomidou, MD Yoshiyuki Hyo, MD Ryo Takagi, MD Takashi Koike, MD Marie Yamada, MD Mitsuhiro Okano, MD |
| author_sort | Aiko Oka, MD |
| collection | DOAJ |
| description | Background: It remains unclear whether allergen immunotherapy with Japanese cedar pollen extract is effective for Japanese cypress pollinosis in real-world settings. Objective: We sought to investigate the Japan-wide prevalence of cypress pollinosis, the efficacy of cedar sublingual immunotherapy (SLIT) on cypress pollinosis, the role of serum-specific IgE levels in pollinosis, and patients’ interest in the development of cypress SLIT. Methods: A cross-sectional, multicenter study using self-administered questionnaires was conducted in regions of Japan where cedar and cypress pollen dispersals are prevalent. This study included patients aged 5 to 69 years who received cedar SLIT in 2023. Results: Of 2597 participants analyzed, 84.5% experienced pollinosis symptoms during the cypress season before receiving cedar SLIT. Among these patients, 40.2% felt that cedar SLIT was less effective during the cypress season than during the cedar season. The longer the patients received cedar SLIT, the greater the inefficacy perceived during the cypress versus the cedar season. In the symptomatic patients, serum IgE levels were significantly higher for cedar and cypress as compared with those observed in subjects without symptoms during the cypress season. No significant differences were reported in IgE levels for cedar and cypress between patients reporting either high or lower efficacy for the cedar SLIT during cypress season. Interest in cypress SLIT was seen in 78.4% of these patients. Conclusions: Although there is a bias based on regional distribution, cedar SLIT has induced a limited efficacy on cypress pollinosis in real-world settings, suggesting a need for the development of cypress SLIT. |
| format | Article |
| id | doaj-art-e786c5eefbc04075beac4080cfd1b64f |
| institution | Matheson Library |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-e786c5eefbc04075beac4080cfd1b64f2025-08-04T04:24:45ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-08-0143100463Real-world efficacy of sublingual immunotherapy with Japanese cedar pollen for cypress pollinosisAiko Oka, MD0Tamami Yamashita, MD1Kengo Kanai, MD2Atsushi Yuta, MD3Yukiko Ogawa, MD4Eriko Takahara, MD5Hideki Shiratsuchi, MD6Akihiko Terada, MD7Takatsugu Tsunoda, MD8Takeshi Masuda, MD9Satoru Masuno, MD10Kenichi Kanai, MD11Hitoshi Nagakura, MD12Reiko Tokuda, MD13Harumi Arao, MD14Hitoshi Bamba, MD15Shigenobu Yasuda, MD16Hideya Mimura, MD17Mahoko Nakazato, MD18Hidehisa Nakazato, MD19Noriyuki Houya, MD20Hideaki Tsuzuki, MD21Masaharu Tokuriki, MD22Mayuko Sakaida, MD23Ryo Amesara, MD24Chikahisa Ohkawa, MD25Takemitsu Hama, MD26Hiroki Ikeda, MD27Hisaki Fukushima, MD28Sumiko Niitsu, MD29Hirofumi Sakaguchi, MD30Norihito Iba, MD31Hiroshi Kumanomidou, MD32Yoshiyuki Hyo, MD33Ryo Takagi, MD34Takashi Koike, MD35Marie Yamada, MD36Mitsuhiro Okano, MD37Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Chiba, JapanFaculty of Medicine, International University of Health and Welfare School of Medicine, Chiba, JapanDepartment of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Chiba, Japan; Department of Otorhinolaryngology, Head and Neck Surgery, Japanese Red Cross Society Himeji Hospital, Hyogo, JapanYuta Clinic, Mie, JapanYuta Clinic, Mie, JapanChofu Ekimae ENT Clinic, Tokyo, JapanShiratsuchi Otorhinolaryngology Clinic, Fukuoka, JapanTerada Allergy Kodomo Clinic, Aichi, JapanHidamari Clinic, Mie, JapanMasuda ENT Clinic, Saitama, JapanMakinohara Nanohana ENT Clinic, Chiba, JapanKosugi ENT Clinic, Kanagawa, JapanNagakura ENT Allergy Clinic, Tokyo, JapanTokuda Family Clinic, Mie, JapanArao Internal Medicine and Otolaryngology Clinic, Aichi, JapanBamba ENT Clinic, Shiga, JapanYasuda Clinic, Kyoto, JapanMimura Clinic, Aichi, JapanAzusawa ENT Clinic, Tokyo, JapanOyamanakamaru Clinic, Tokyo, JapanOizumigakuen ENT Clinic, Tokyo, JapanMiyako Ear, Nose and Throat Clinic, Aichi, JapanTokuriki ENT Clinic, Mie, JapanMie ENT Clinic, Mie, JapanAmesara ENT Clinic, Mie, JapanOhkawa ENT Clinic, Mie, JapanHama ENT Clinic, Kyoto, JapanIkeda ENT Clinic, Wakayama, JapanFukushima Clinic, Okayama, JapanNiitsu Clinic, Okayama, JapanE.N.T. Sakaguchi Clinic, Shiga, JapanMinna-no-kodomo Allergy Clinic, Wakayama, JapanKumanomidou ENT Clinic, Tokyo, JapanHyo ENT Clinic, Kyoto, JapanDepartment of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Chiba, JapanDepartment of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Chiba, JapanDepartment of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Chiba, JapanDepartment of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Chiba, Japan; Corresponding author: Mitsuhiro Okano, MD, Department of Otorhinolaryngology, Head & Neck Surgery, International University of Health and Welfare Narita Hospital, 852 Hatakeda, Narita 286-8520, Japan.Background: It remains unclear whether allergen immunotherapy with Japanese cedar pollen extract is effective for Japanese cypress pollinosis in real-world settings. Objective: We sought to investigate the Japan-wide prevalence of cypress pollinosis, the efficacy of cedar sublingual immunotherapy (SLIT) on cypress pollinosis, the role of serum-specific IgE levels in pollinosis, and patients’ interest in the development of cypress SLIT. Methods: A cross-sectional, multicenter study using self-administered questionnaires was conducted in regions of Japan where cedar and cypress pollen dispersals are prevalent. This study included patients aged 5 to 69 years who received cedar SLIT in 2023. Results: Of 2597 participants analyzed, 84.5% experienced pollinosis symptoms during the cypress season before receiving cedar SLIT. Among these patients, 40.2% felt that cedar SLIT was less effective during the cypress season than during the cedar season. The longer the patients received cedar SLIT, the greater the inefficacy perceived during the cypress versus the cedar season. In the symptomatic patients, serum IgE levels were significantly higher for cedar and cypress as compared with those observed in subjects without symptoms during the cypress season. No significant differences were reported in IgE levels for cedar and cypress between patients reporting either high or lower efficacy for the cedar SLIT during cypress season. Interest in cypress SLIT was seen in 78.4% of these patients. Conclusions: Although there is a bias based on regional distribution, cedar SLIT has induced a limited efficacy on cypress pollinosis in real-world settings, suggesting a need for the development of cypress SLIT.http://www.sciencedirect.com/science/article/pii/S2772829325000645EfficacyIgEJapanese cedar pollenJapanese cypress pollenpollinosisprevalence |
| spellingShingle | Aiko Oka, MD Tamami Yamashita, MD Kengo Kanai, MD Atsushi Yuta, MD Yukiko Ogawa, MD Eriko Takahara, MD Hideki Shiratsuchi, MD Akihiko Terada, MD Takatsugu Tsunoda, MD Takeshi Masuda, MD Satoru Masuno, MD Kenichi Kanai, MD Hitoshi Nagakura, MD Reiko Tokuda, MD Harumi Arao, MD Hitoshi Bamba, MD Shigenobu Yasuda, MD Hideya Mimura, MD Mahoko Nakazato, MD Hidehisa Nakazato, MD Noriyuki Houya, MD Hideaki Tsuzuki, MD Masaharu Tokuriki, MD Mayuko Sakaida, MD Ryo Amesara, MD Chikahisa Ohkawa, MD Takemitsu Hama, MD Hiroki Ikeda, MD Hisaki Fukushima, MD Sumiko Niitsu, MD Hirofumi Sakaguchi, MD Norihito Iba, MD Hiroshi Kumanomidou, MD Yoshiyuki Hyo, MD Ryo Takagi, MD Takashi Koike, MD Marie Yamada, MD Mitsuhiro Okano, MD Real-world efficacy of sublingual immunotherapy with Japanese cedar pollen for cypress pollinosis Journal of Allergy and Clinical Immunology: Global Efficacy IgE Japanese cedar pollen Japanese cypress pollen pollinosis prevalence |
| title | Real-world efficacy of sublingual immunotherapy with Japanese cedar pollen for cypress pollinosis |
| title_full | Real-world efficacy of sublingual immunotherapy with Japanese cedar pollen for cypress pollinosis |
| title_fullStr | Real-world efficacy of sublingual immunotherapy with Japanese cedar pollen for cypress pollinosis |
| title_full_unstemmed | Real-world efficacy of sublingual immunotherapy with Japanese cedar pollen for cypress pollinosis |
| title_short | Real-world efficacy of sublingual immunotherapy with Japanese cedar pollen for cypress pollinosis |
| title_sort | real world efficacy of sublingual immunotherapy with japanese cedar pollen for cypress pollinosis |
| topic | Efficacy IgE Japanese cedar pollen Japanese cypress pollen pollinosis prevalence |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325000645 |
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