LAMP3 expression correlated with poor clinical outcome in human ovarian cancer
Lysosome-associated membrane protein 3 belongs to the lysosome-associated membrane glycoprotein family, which is associated with lymph node, metastasis, poor overall survival, and resistance to chemotherapy and radiotherapy. Epithelial ovarian cancer is one of the most deadly global female gynecolog...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-03-01
|
| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317695014 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839596000231030784 |
|---|---|
| author | Di Wang Xuemin Cao Yuquan Zhang Yuanlin Liu Chan Yao Wenliang Ge Yunzhao Xu |
| author_facet | Di Wang Xuemin Cao Yuquan Zhang Yuanlin Liu Chan Yao Wenliang Ge Yunzhao Xu |
| author_sort | Di Wang |
| collection | DOAJ |
| description | Lysosome-associated membrane protein 3 belongs to the lysosome-associated membrane glycoprotein family, which is associated with lymph node, metastasis, poor overall survival, and resistance to chemotherapy and radiotherapy. Epithelial ovarian cancer is one of the most deadly global female gynecologic malignant tumors. Its clinical outcome is poor and most epithelial ovarian cancer patients tend to relapse because of drug resistance. However, lysosome-associated membrane protein 3 expression in epithelial ovarian cancer and its relationship between clinicopathologic factors remain poorly understood. To clarify the prognostic implications of lysosome-associated membrane protein 3 in epithelial ovarian cancer, we analyzed both messenger RNA and protein levels of lysosome-associated membrane protein 3 in ovarian carcinomas. Polymerase chain reaction results showed higher expression of lysosome-associated membrane protein 3 messenger RNA in epithelial ovarian cancer than in noncancerous tissues. Immunohistochemical results showed that high lysosome-associated membrane protein 3 cytoplasmic expression was significantly related to tumor grade ( p = 0.038), lymph node metastasis ( p = 0.049), metastasis ( p < 0.001), level of CA125 ( p = 0.030), and International Federation of Gynecology and Obstetrics (FIGO) ( p < 0.001). High lysosome-associated membrane protein 3 nuclear expression was significantly associated with tumor grade ( p = 0.046), tumor single or double (representative whether the tumor involving one or both ovaries) ( p = 0.016), metastasis ( p < 0.001), and FIGO stage ( p < 0.001). Survival analysis indicated that high lysosome-associated membrane protein 3 cytoplasmic expression (hazard ratio: 4.632, 95% confidence interval: 2.421–8.864; p < 0.001), patients’ age (hazard ratio: 1.729, 95% confidence interval: 1.027–2.911; p = 0.039), and FIGO stage (hazard ratio: 2.049, 95% confidence interval: 1.113–3.774; p = 0.021) were significantly correlated with poor survival outcome of epithelial ovarian cancer patients. |
| format | Article |
| id | doaj-art-e779f996c0714ecf8e2b29d577a4e910 |
| institution | Matheson Library |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-e779f996c0714ecf8e2b29d577a4e9102025-08-02T22:11:45ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317695014LAMP3 expression correlated with poor clinical outcome in human ovarian cancerDi Wang0Xuemin Cao1Yuquan Zhang2Yuanlin Liu3Chan Yao4Wenliang Ge5Yunzhao Xu6Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Biology, Nantong University, Nantong, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Pathology, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, ChinaLysosome-associated membrane protein 3 belongs to the lysosome-associated membrane glycoprotein family, which is associated with lymph node, metastasis, poor overall survival, and resistance to chemotherapy and radiotherapy. Epithelial ovarian cancer is one of the most deadly global female gynecologic malignant tumors. Its clinical outcome is poor and most epithelial ovarian cancer patients tend to relapse because of drug resistance. However, lysosome-associated membrane protein 3 expression in epithelial ovarian cancer and its relationship between clinicopathologic factors remain poorly understood. To clarify the prognostic implications of lysosome-associated membrane protein 3 in epithelial ovarian cancer, we analyzed both messenger RNA and protein levels of lysosome-associated membrane protein 3 in ovarian carcinomas. Polymerase chain reaction results showed higher expression of lysosome-associated membrane protein 3 messenger RNA in epithelial ovarian cancer than in noncancerous tissues. Immunohistochemical results showed that high lysosome-associated membrane protein 3 cytoplasmic expression was significantly related to tumor grade ( p = 0.038), lymph node metastasis ( p = 0.049), metastasis ( p < 0.001), level of CA125 ( p = 0.030), and International Federation of Gynecology and Obstetrics (FIGO) ( p < 0.001). High lysosome-associated membrane protein 3 nuclear expression was significantly associated with tumor grade ( p = 0.046), tumor single or double (representative whether the tumor involving one or both ovaries) ( p = 0.016), metastasis ( p < 0.001), and FIGO stage ( p < 0.001). Survival analysis indicated that high lysosome-associated membrane protein 3 cytoplasmic expression (hazard ratio: 4.632, 95% confidence interval: 2.421–8.864; p < 0.001), patients’ age (hazard ratio: 1.729, 95% confidence interval: 1.027–2.911; p = 0.039), and FIGO stage (hazard ratio: 2.049, 95% confidence interval: 1.113–3.774; p = 0.021) were significantly correlated with poor survival outcome of epithelial ovarian cancer patients.https://doi.org/10.1177/1010428317695014 |
| spellingShingle | Di Wang Xuemin Cao Yuquan Zhang Yuanlin Liu Chan Yao Wenliang Ge Yunzhao Xu LAMP3 expression correlated with poor clinical outcome in human ovarian cancer Tumor Biology |
| title | LAMP3 expression correlated with poor clinical outcome in human ovarian cancer |
| title_full | LAMP3 expression correlated with poor clinical outcome in human ovarian cancer |
| title_fullStr | LAMP3 expression correlated with poor clinical outcome in human ovarian cancer |
| title_full_unstemmed | LAMP3 expression correlated with poor clinical outcome in human ovarian cancer |
| title_short | LAMP3 expression correlated with poor clinical outcome in human ovarian cancer |
| title_sort | lamp3 expression correlated with poor clinical outcome in human ovarian cancer |
| url | https://doi.org/10.1177/1010428317695014 |
| work_keys_str_mv | AT diwang lamp3expressioncorrelatedwithpoorclinicaloutcomeinhumanovariancancer AT xuemincao lamp3expressioncorrelatedwithpoorclinicaloutcomeinhumanovariancancer AT yuquanzhang lamp3expressioncorrelatedwithpoorclinicaloutcomeinhumanovariancancer AT yuanlinliu lamp3expressioncorrelatedwithpoorclinicaloutcomeinhumanovariancancer AT chanyao lamp3expressioncorrelatedwithpoorclinicaloutcomeinhumanovariancancer AT wenliangge lamp3expressioncorrelatedwithpoorclinicaloutcomeinhumanovariancancer AT yunzhaoxu lamp3expressioncorrelatedwithpoorclinicaloutcomeinhumanovariancancer |