The Anticancer Effect of Genistein Through Enhancing PERK Signaling and Suppressing the IRE1α-XBP1 Axis in Canine Mammary Gland Tumor Cells

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The Anticancer Effect of Genistein Through Enhancing PERK Signaling and Suppressing the IRE1α-XBP1 Axis in Canine Mammary Gland Tumor Cells

Genistein, a natural isoflavone, exerts anticancer effects on human breast cancer cells by modulating the unfolded protein response (UPR). However, the effect of genistein on UPR in canine mammary gland tumor (CMT) cells remains unknown. The aim of the present study was to investigate the anticancer...

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Bibliographic Details
Main Authors:	Ye-Ji Jang, Min-Jae Yoo, Hyuk Jang, Jun Song, Sang-Youel Park, Jawun Choi, Jae-Won Seol
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Animals
Subjects:	canine mammary gland tumors CMT-U27 genistein unfolded protein response estrogen receptor alpha
Online Access:	https://www.mdpi.com/2076-2615/15/12/1717
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