TNFα stimulates osteoclastogenesis and expression of CX3CL1 in non-adherent bone marrow cells

TNFα stimulates osteoclastogenesis and expression of CX3CL1 in non-adherent bone marrow cells

The balance between bone formation by osteoblasts and bone resorption by osteoclasts is a critical step in maintaining bone homeostasis. Excessive activation of osteoclasts is important in the bone destruction seen in diseases such as osteoporosis and rheumatoid arthritis. The microenvironment aroun...

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Bibliographic Details
Main Authors: Yuto Otsuka, Narumi Hattori, Hiromasa Aoki, Kohki Toriuchi, Yasumichi Inoue, Hidetoshi Hayashi, Gen Kuroyanagi, Yohei Kawaguchi, Yuko Waguri-Nagaya, Mineyoshi Aoyama
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Osteoclast
TNFα
Chemokine
Microenvironment
Rheumatoid arthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825002420
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