Use of Model‐Based Meta‐Analysis to Inform the Design of Early Clinical Trials of Anti‐Amyloid Beta Therapies in Alzheimer's Disease
ABSTRACT To inform an efficient development of new investigational anti‐amyloid beta (anti‐Aβ) monoclonal antibodies (mAbs), a modeling‐and‐simulation‐based strategy was proposed. A general modeling framework that links drug exposures to the time course of amyloid plaque removal and amyloid‐related...
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| Главные авторы: | , , , , |
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| Формат: | Статья |
| Язык: | английский |
| Опубликовано: |
Wiley
2025-07-01
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| Серии: | CPT: Pharmacometrics & Systems Pharmacology |
| Предметы: | |
| Online-ссылка: | https://doi.org/10.1002/psp4.70038 |
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