Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older Adults
Background The aim of this study was to examine the effects of different levels of physical activity on functional capacity, muscle strength, and the contractile properties of single muscle fibers in older adults. Methods Twenty-ones older adults (71.1±3.7 years) were divided into the high physical...
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Korea Geriatrics Society
2025-06-01
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| Series: | Annals of Geriatric Medicine and Research |
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| Online Access: | http://www.e-agmr.org/upload/pdf/agmr-24-0141.pdf |
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| author | Hyo-Seong Yeo Jae-Young Lim |
| author_facet | Hyo-Seong Yeo Jae-Young Lim |
| author_sort | Hyo-Seong Yeo |
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| description | Background The aim of this study was to examine the effects of different levels of physical activity on functional capacity, muscle strength, and the contractile properties of single muscle fibers in older adults. Methods Twenty-ones older adults (71.1±3.7 years) were divided into the high physical activity (HPA, n=10) and low physical activity (LPA, n=11) groups. Physical activity was assessed using a short form of the International Physical Activity Questionnaire (IPAQ). Physical function and muscle strength tests were performed. The fiber cross-sectional area (CSA), maximal force (Po), maximal force normalized to CSA (specific force, SF), maximal shortening velocity (Vo), and myosin heavy chain isoform expression were determined in single muscle fibers. Results IPAQ walking and total scores were higher in the HPA than in the LPA. The differences in body composition of the LPA and HPA were not significant. The 4-m walking velocity and isometric and isokinetic knee extensor strength were higher in the HPA than in the LPA. There was a significant difference between the two groups in Vo, but not fiber CSA, peak force, and SF. In addition, the Vo was significantly higher in the HPA than in the LPA for type I but not type II fibers. The correlation between total physical activity level and Vo was positive. Conclusion In older adults, higher levels of physical activity may have a greater impact on muscle function than on body composition. Moreover, increased physical activity is associated with higher Vo at the muscle cell level. Thus, we propose that enhancing overall physical activity levels should be considered an effective strategy for improving muscle function in older adults. |
| format | Article |
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| institution | Matheson Library |
| issn | 2508-4798 2508-4909 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Korea Geriatrics Society |
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| series | Annals of Geriatric Medicine and Research |
| spelling | doaj-art-e5ec554d42ba45d7b0e6e2a2fc6b45192025-07-02T07:12:15ZengKorea Geriatrics SocietyAnnals of Geriatric Medicine and Research2508-47982508-49092025-06-0129225426410.4235/agmr.24.01411175Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older AdultsHyo-Seong Yeo0Jae-Young Lim1 Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaBackground The aim of this study was to examine the effects of different levels of physical activity on functional capacity, muscle strength, and the contractile properties of single muscle fibers in older adults. Methods Twenty-ones older adults (71.1±3.7 years) were divided into the high physical activity (HPA, n=10) and low physical activity (LPA, n=11) groups. Physical activity was assessed using a short form of the International Physical Activity Questionnaire (IPAQ). Physical function and muscle strength tests were performed. The fiber cross-sectional area (CSA), maximal force (Po), maximal force normalized to CSA (specific force, SF), maximal shortening velocity (Vo), and myosin heavy chain isoform expression were determined in single muscle fibers. Results IPAQ walking and total scores were higher in the HPA than in the LPA. The differences in body composition of the LPA and HPA were not significant. The 4-m walking velocity and isometric and isokinetic knee extensor strength were higher in the HPA than in the LPA. There was a significant difference between the two groups in Vo, but not fiber CSA, peak force, and SF. In addition, the Vo was significantly higher in the HPA than in the LPA for type I but not type II fibers. The correlation between total physical activity level and Vo was positive. Conclusion In older adults, higher levels of physical activity may have a greater impact on muscle function than on body composition. Moreover, increased physical activity is associated with higher Vo at the muscle cell level. Thus, we propose that enhancing overall physical activity levels should be considered an effective strategy for improving muscle function in older adults.http://www.e-agmr.org/upload/pdf/agmr-24-0141.pdfagingphysical activityvelocitymuscle fibermuscle strength |
| spellingShingle | Hyo-Seong Yeo Jae-Young Lim Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older Adults Annals of Geriatric Medicine and Research aging physical activity velocity muscle fiber muscle strength |
| title | Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older Adults |
| title_full | Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older Adults |
| title_fullStr | Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older Adults |
| title_full_unstemmed | Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older Adults |
| title_short | Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older Adults |
| title_sort | impact of physical activity level on whole body and muscle cell function in older adults |
| topic | aging physical activity velocity muscle fiber muscle strength |
| url | http://www.e-agmr.org/upload/pdf/agmr-24-0141.pdf |
| work_keys_str_mv | AT hyoseongyeo impactofphysicalactivitylevelonwholebodyandmusclecellfunctioninolderadults AT jaeyounglim impactofphysicalactivitylevelonwholebodyandmusclecellfunctioninolderadults |