Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives
Aim. Currently, researches, devoted to obtain new active compounds, are carried out among various classes of organic compounds, and combination of several active heterocyclic fragments in one molecule is considered the key way in such researches. Methods and results. For this purpose, we have dev...
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| Format: | Article |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-08-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/45108/43752 |
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| author | K. V. Аleksandrova A. S. Shkoda S. V. Levich M. V. Dyachkov D. M. Yurchenko |
| author_facet | K. V. Аleksandrova A. S. Shkoda S. V. Levich M. V. Dyachkov D. M. Yurchenko |
| author_sort | K. V. Аleksandrova |
| collection | DOAJ |
| description | Aim. Currently, researches, devoted to obtain new active compounds, are carried out among various classes of organic compounds, and combination of several active heterocyclic fragments in one molecule is considered the key way in such researches.
Methods and results. For this purpose, we have developed a preparative method of synthesis of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its S-substituted derivatives. On example of propyl ester of [5-(3-benzylxanthinyl-8-methylthiomethyl)-4-phenyl-[1,2,4]triazole-3-yl]thioacetic acid the possibility of further functionalization of triazolylmethylthiomethylxanthines has been shown.
Conclusion. The structures and identity of all synthesized compounds have been proved by elemental analysis, IR-, 1H NMR-spectroscopy, mass-spectrometry and by thin layer chromatography. |
| format | Article |
| id | doaj-art-e56e2dda03fa4e69b6034c4c00de6ff9 |
| institution | Matheson Library |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2015-08-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-e56e2dda03fa4e69b6034c4c00de6ff92025-08-02T21:59:16ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322015-08-012495410.14739/2409-2932.2015.2.45108Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivativesK. V. АleksandrovaA. S. ShkodaS. V. LevichM. V. DyachkovD. M. YurchenkoAim. Currently, researches, devoted to obtain new active compounds, are carried out among various classes of organic compounds, and combination of several active heterocyclic fragments in one molecule is considered the key way in such researches. Methods and results. For this purpose, we have developed a preparative method of synthesis of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its S-substituted derivatives. On example of propyl ester of [5-(3-benzylxanthinyl-8-methylthiomethyl)-4-phenyl-[1,2,4]triazole-3-yl]thioacetic acid the possibility of further functionalization of triazolylmethylthiomethylxanthines has been shown. Conclusion. The structures and identity of all synthesized compounds have been proved by elemental analysis, IR-, 1H NMR-spectroscopy, mass-spectrometry and by thin layer chromatography.http://pharmed.zsmu.edu.ua/article/view/45108/43752XanthinesOrganic SynthesisInfrared-SpectroscopyNMR-spectroscopy |
| spellingShingle | K. V. Аleksandrova A. S. Shkoda S. V. Levich M. V. Dyachkov D. M. Yurchenko Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Xanthines Organic Synthesis Infrared-Spectroscopy NMR-spectroscopy |
| title | Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives |
| title_full | Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives |
| title_fullStr | Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives |
| title_full_unstemmed | Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives |
| title_short | Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives |
| title_sort | synthesis and physical chemical properties of 3 benzyl 8 5 mercapto 4 phenyl 1 2 4 triazole 3 ylmethylthiomethyl xanthine and its s substituted derivatives |
| topic | Xanthines Organic Synthesis Infrared-Spectroscopy NMR-spectroscopy |
| url | http://pharmed.zsmu.edu.ua/article/view/45108/43752 |
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