FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway

FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway

The pathogenesis and chemoresistance mechanisms of colon cancer (CC) are still unclear. Here, we find that a long non-coding RNA (lncRNA), FEZ family zinc finger 1-antisense RNA 1 (FEZF1-AS1), is highly expressed in CC, which may be caused by the amplification mutation of FEZF1-AS1 at the gene level...

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Bibliographic Details
Main Authors: Xiaoping Yang, Zuohui Yuan, Lingzhu Gou, Long Cheng, Zirui Wang, Pingfan Wu, Xiaochun Wang, Xueni Ma, Tiantian Ma, Yi Yu, Zhiping Wu, Dekui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Genetics
Subjects:
FEZF1-AS1
colon cancer
autophagy
PI3K/AKT/mTOR
chemosensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1514205/full
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