Modern concepts of the mycosis fungoides pathogenesis
Mycosis fungoides – the most common form of cutaneous T-cell lymphoma. The pathogenesis of this disease is complex and remains unclear. The article contains a review of the literature devoted to the main mechanisms of T-lymphocytes malignant proliferation, known to date. Data on dysregulation of imm...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2018-10-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/305 |
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| author | A. A. Vorontsova A. E. Karamova L. F. Znamenskaya |
| author_facet | A. A. Vorontsova A. E. Karamova L. F. Znamenskaya |
| author_sort | A. A. Vorontsova |
| collection | DOAJ |
| description | Mycosis fungoides – the most common form of cutaneous T-cell lymphoma. The pathogenesis of this disease is complex and remains unclear. The article contains a review of the literature devoted to the main mechanisms of T-lymphocytes malignant proliferation, known to date. Data on dysregulation of immune, genetic and epigenetic mechanisms, as well as the role of microenvironment cells in the proliferation of T lymphocytes, are given. Immunophenotypic characteristics and cellular composition of the infiltrate in patients with mycosis fungoides, are described depending on the stage of the disease. Prospective directions in studying molecular-biological predictors of malignant lymphoproliferative diseases development are highlighted. |
| format | Article |
| id | doaj-art-e4d3d43f8391497f95b75e02097c14d0 |
| institution | Matheson Library |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2018-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-e4d3d43f8391497f95b75e02097c14d02025-08-04T13:57:50ZrusABV-pressОнкогематология1818-83462413-40232018-10-01133394610.17650/1818-8346-2018-13-3-39-46278Modern concepts of the mycosis fungoides pathogenesisA. A. Vorontsova0A. E. Karamova1L. F. Znamenskaya2State Scientific Center of Dermatovenerology and Cosmetology, Ministry of Health of Russia.State Scientific Center of Dermatovenerology and Cosmetology, Ministry of Health of Russia.State Scientific Center of Dermatovenerology and Cosmetology, Ministry of Health of Russia.Mycosis fungoides – the most common form of cutaneous T-cell lymphoma. The pathogenesis of this disease is complex and remains unclear. The article contains a review of the literature devoted to the main mechanisms of T-lymphocytes malignant proliferation, known to date. Data on dysregulation of immune, genetic and epigenetic mechanisms, as well as the role of microenvironment cells in the proliferation of T lymphocytes, are given. Immunophenotypic characteristics and cellular composition of the infiltrate in patients with mycosis fungoides, are described depending on the stage of the disease. Prospective directions in studying molecular-biological predictors of malignant lymphoproliferative diseases development are highlighted.https://oncohematology.abvpress.ru/ongm/article/view/305cutaneous t-cell lymphomamycosis fungoidesmechanisms of developmentpathogenesiscytokinesinterleukint-lymphocytessignaling proteinsmicro-rna |
| spellingShingle | A. A. Vorontsova A. E. Karamova L. F. Znamenskaya Modern concepts of the mycosis fungoides pathogenesis Онкогематология cutaneous t-cell lymphoma mycosis fungoides mechanisms of development pathogenesis cytokines interleukin t-lymphocytes signaling proteins micro-rna |
| title | Modern concepts of the mycosis fungoides pathogenesis |
| title_full | Modern concepts of the mycosis fungoides pathogenesis |
| title_fullStr | Modern concepts of the mycosis fungoides pathogenesis |
| title_full_unstemmed | Modern concepts of the mycosis fungoides pathogenesis |
| title_short | Modern concepts of the mycosis fungoides pathogenesis |
| title_sort | modern concepts of the mycosis fungoides pathogenesis |
| topic | cutaneous t-cell lymphoma mycosis fungoides mechanisms of development pathogenesis cytokines interleukin t-lymphocytes signaling proteins micro-rna |
| url | https://oncohematology.abvpress.ru/ongm/article/view/305 |
| work_keys_str_mv | AT aavorontsova modernconceptsofthemycosisfungoidespathogenesis AT aekaramova modernconceptsofthemycosisfungoidespathogenesis AT lfznamenskaya modernconceptsofthemycosisfungoidespathogenesis |