Pancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case report
Abstract Background Pancreatic acinar cell carcinoma (PACC) is a rare exocrine malignant tumor. Its widespread intraductal extension into the main pancreatic duct (MPD) is also rare. Case presentation We report the case of a 71-year-old man with PACC with MPD extension. The patient was assessed with...
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Japan Surgical Society
2021-04-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-021-01172-0 |
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| author | Masato Kayahara Ichiro Onishi Naoki Makita Shunsuke Kano Masayoshi Munemoto Yasumichi Yagi Makiko Minami Noriaki Orita Takuya Komura Nozomu Kurose |
| author_facet | Masato Kayahara Ichiro Onishi Naoki Makita Shunsuke Kano Masayoshi Munemoto Yasumichi Yagi Makiko Minami Noriaki Orita Takuya Komura Nozomu Kurose |
| author_sort | Masato Kayahara |
| collection | DOAJ |
| description | Abstract Background Pancreatic acinar cell carcinoma (PACC) is a rare exocrine malignant tumor. Its widespread intraductal extension into the main pancreatic duct (MPD) is also rare. Case presentation We report the case of a 71-year-old man with PACC with MPD extension. The patient was assessed with laboratory and radiographic investigations that facilitated a preoperative diagnosis. Endoscopic ultrasonography (EUS) and dynamic thin-slice multi-detector row computed tomography (MDCT) were useful for determining the resection line of the pancreas. EUS-guided fine needle aspiration (EUS-FNA) was also helpful in determining the tumor biology and treatment strategy. Distal pancreatectomy was performed. The MPD was occupied by the tumor 35 mm downstream and 5 mm upstream. Histopathologically, the pancreatic tail tumor extended continuously into the MPD. The tumor was solid with cells showing eosinophilic and granular cytoplasm, indicating the diagnosis of PACC. This is an interesting case of PACC with intraductal extension into the MPD. We discuss the possible mechanisms of tumor extension in this rare case together with a review of the literature. Conclusions We describe a rare pancreatic acinar cell carcinoma that could be adequately treated using preoperative precise imaging and histopathological evaluations. When an intraductal tumor extension in the MPD is encountered, the diagnosis of a rare pancreatic tumor should be considered, as in our case. |
| format | Article |
| id | doaj-art-e4d382438a074c02a1e48f0d92f15c68 |
| institution | Matheson Library |
| issn | 2198-7793 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-e4d382438a074c02a1e48f0d92f15c682025-08-02T21:56:21ZengJapan Surgical SocietySurgical Case Reports2198-77932021-04-01711610.1186/s40792-021-01172-0Pancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case reportMasato Kayahara0Ichiro Onishi1Naoki Makita2Shunsuke Kano3Masayoshi Munemoto4Yasumichi Yagi5Makiko Minami6Noriaki Orita7Takuya Komura8Nozomu Kurose9Department of Surgery, NHO Kanazawa Medical CenterDepartment of Surgery, NHO Kanazawa Medical CenterDepartment of Surgery, NHO Kanazawa Medical CenterDepartment of Surgery, NHO Kanazawa Medical CenterDepartment of Surgery, NHO Kanazawa Medical CenterDepartment of Surgery, NHO Kanazawa Medical CenterDepartment of Radiology, NHO Kanazawa Medical CenterDepartment of Gastroenterology, NHO Kanazawa Medical CenterDepartment of Gastroenterology, NHO Kanazawa Medical CenterDepartment of Pathology, NHO Kanazawa Medical CenterAbstract Background Pancreatic acinar cell carcinoma (PACC) is a rare exocrine malignant tumor. Its widespread intraductal extension into the main pancreatic duct (MPD) is also rare. Case presentation We report the case of a 71-year-old man with PACC with MPD extension. The patient was assessed with laboratory and radiographic investigations that facilitated a preoperative diagnosis. Endoscopic ultrasonography (EUS) and dynamic thin-slice multi-detector row computed tomography (MDCT) were useful for determining the resection line of the pancreas. EUS-guided fine needle aspiration (EUS-FNA) was also helpful in determining the tumor biology and treatment strategy. Distal pancreatectomy was performed. The MPD was occupied by the tumor 35 mm downstream and 5 mm upstream. Histopathologically, the pancreatic tail tumor extended continuously into the MPD. The tumor was solid with cells showing eosinophilic and granular cytoplasm, indicating the diagnosis of PACC. This is an interesting case of PACC with intraductal extension into the MPD. We discuss the possible mechanisms of tumor extension in this rare case together with a review of the literature. Conclusions We describe a rare pancreatic acinar cell carcinoma that could be adequately treated using preoperative precise imaging and histopathological evaluations. When an intraductal tumor extension in the MPD is encountered, the diagnosis of a rare pancreatic tumor should be considered, as in our case.https://doi.org/10.1186/s40792-021-01172-0Pancreatic acinar cell carcinomaMain pancreatic duct extensionEUS-FNA |
| spellingShingle | Masato Kayahara Ichiro Onishi Naoki Makita Shunsuke Kano Masayoshi Munemoto Yasumichi Yagi Makiko Minami Noriaki Orita Takuya Komura Nozomu Kurose Pancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case report Surgical Case Reports Pancreatic acinar cell carcinoma Main pancreatic duct extension EUS-FNA |
| title | Pancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case report |
| title_full | Pancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case report |
| title_fullStr | Pancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case report |
| title_full_unstemmed | Pancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case report |
| title_short | Pancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case report |
| title_sort | pancreatic acinar cell carcinoma with extension into the main pancreatic duct a case report |
| topic | Pancreatic acinar cell carcinoma Main pancreatic duct extension EUS-FNA |
| url | https://doi.org/10.1186/s40792-021-01172-0 |
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