Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case report
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder which occurs due to excessive immune response and high cytokine levels leading to tissue damage and organ failure. HLH can be primary and secondary. The etiology and presentation of secondary HLH remain diverse. Treatment of sec...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Allergy Asthma and Immunology |
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| Online Access: | https://journals.lww.com/10.4103/ijaai.ijaai_64_24 |
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| author | Rahul Kumar Gupta Sammi Pundir Mansi Kala Avriti Baveja Pranshul Rawat Anuradha Khandelwal |
| author_facet | Rahul Kumar Gupta Sammi Pundir Mansi Kala Avriti Baveja Pranshul Rawat Anuradha Khandelwal |
| author_sort | Rahul Kumar Gupta |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder which occurs due to excessive immune response and high cytokine levels leading to tissue damage and organ failure. HLH can be primary and secondary. The etiology and presentation of secondary HLH remain diverse. Treatment of secondary HLH includes management of primary conditions and immunosuppressives. Several cases of secondary HLH due to tuberculosis (TB) have been reported in the past although their management beyond antitubercular therapy and follow-up was not reported. Here, we present a rare case report of secondary HLH and isolated cerebellar ataxia due to disseminated TB that responded to intravenous immunoglobulin in addition to antitubercular therapy and steroids. Patients showed complete response to therapy with normalization of hematological parameters and bone marrow findings. The patient was declared cured after 6 months of treatment. |
| format | Article |
| id | doaj-art-e46eda79bcc945e6b32f5fc93cbf9999 |
| institution | Matheson Library |
| issn | 0972-6691 2320-4745 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Allergy Asthma and Immunology |
| spelling | doaj-art-e46eda79bcc945e6b32f5fc93cbf99992025-07-04T12:19:03ZengWolters Kluwer Medknow PublicationsIndian Journal of Allergy Asthma and Immunology0972-66912320-47452025-01-01391293210.4103/ijaai.ijaai_64_24Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case reportRahul Kumar GuptaSammi PundirMansi KalaAvriti BavejaPranshul RawatAnuradha KhandelwalHemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder which occurs due to excessive immune response and high cytokine levels leading to tissue damage and organ failure. HLH can be primary and secondary. The etiology and presentation of secondary HLH remain diverse. Treatment of secondary HLH includes management of primary conditions and immunosuppressives. Several cases of secondary HLH due to tuberculosis (TB) have been reported in the past although their management beyond antitubercular therapy and follow-up was not reported. Here, we present a rare case report of secondary HLH and isolated cerebellar ataxia due to disseminated TB that responded to intravenous immunoglobulin in addition to antitubercular therapy and steroids. Patients showed complete response to therapy with normalization of hematological parameters and bone marrow findings. The patient was declared cured after 6 months of treatment.https://journals.lww.com/10.4103/ijaai.ijaai_64_24intravenous immunoglobulin in secondary hemophagocytic lymphohistiocytosisisolated cerebellar ataxia and secondary hemophagocytic lymphohistiocytosistuberculosis and hemophagocytic lymphohistiocytosis |
| spellingShingle | Rahul Kumar Gupta Sammi Pundir Mansi Kala Avriti Baveja Pranshul Rawat Anuradha Khandelwal Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case report Indian Journal of Allergy Asthma and Immunology intravenous immunoglobulin in secondary hemophagocytic lymphohistiocytosis isolated cerebellar ataxia and secondary hemophagocytic lymphohistiocytosis tuberculosis and hemophagocytic lymphohistiocytosis |
| title | Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case report |
| title_full | Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case report |
| title_fullStr | Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case report |
| title_full_unstemmed | Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case report |
| title_short | Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case report |
| title_sort | secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management a rare case report |
| topic | intravenous immunoglobulin in secondary hemophagocytic lymphohistiocytosis isolated cerebellar ataxia and secondary hemophagocytic lymphohistiocytosis tuberculosis and hemophagocytic lymphohistiocytosis |
| url | https://journals.lww.com/10.4103/ijaai.ijaai_64_24 |
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