Synthetic Study on Bicyclic Pyranonaphthoquinone Natural Products: Construction of the Dioxabicyclo[3.3.1]nonene Motif
A concise method for the construction of dioxabicyclo[3.3.1]nonene framework has been developed. This structural motif has recently been identified in hybrid‐type pyranonaphthoquinone‐class natural products. The reaction proceeds in a stereoselective manner under mild conditions. In conjunction with...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2025-07-01
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| Series: | ChemistryEurope |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ceur.202500086 |
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| Summary: | A concise method for the construction of dioxabicyclo[3.3.1]nonene framework has been developed. This structural motif has recently been identified in hybrid‐type pyranonaphthoquinone‐class natural products. The reaction proceeds in a stereoselective manner under mild conditions. In conjunction with this study, the scalable total syntheses of nanaomycins A and D have been achieved. Based on extensive screening of reaction conditions and nucleophiles, a plausible reaction mechanism is proposed. |
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| ISSN: | 2751-4765 |