Structural Polymorphism of Genome Islands Encoding Resistance to Beta-Lactams in Coagulase-Negative Staphylococci Isolated at Hospitals of the Russian Federation
Coagulase-negative staphylococci (CoNS) are considered as a reservoir of mobile genetic elements and first of all of the staphylococcal cassette chromosome mec (SCCmec), defining staphylococci resistance to beta-lactams. Types II, IV, IVa, V, VII and VIII SCCmec were detected among 95 staphylococcal...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
|
| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/605 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839591205623562240 |
|---|---|
| author | O. A. Dmitrenko A. S. Ankirskaya L. A. Lyubasovskaya O. V. Kovalishena D. A. Popov V. V. Gostev S. V. Sidorenko |
| author_facet | O. A. Dmitrenko A. S. Ankirskaya L. A. Lyubasovskaya O. V. Kovalishena D. A. Popov V. V. Gostev S. V. Sidorenko |
| author_sort | O. A. Dmitrenko |
| collection | DOAJ |
| description | Coagulase-negative staphylococci (CoNS) are considered as a reservoir of mobile genetic elements and first of all of the staphylococcal cassette chromosome mec (SCCmec), defining staphylococci resistance to beta-lactams. Types II, IV, IVa, V, VII and VIII SCCmec were detected among 95 staphylococcal strains isolated in different regions of the Russian Federation. Subtypes Cla, Clb, Clc and Cl SCCmec were also identified (class B mec complex and two complexes of ccrl and ccr2 genes recombinases). Some other cassette types carrying A, C1 and C2 classes of the mec complexes in combination with various recombinase genes were detected. The S.epidermidis isolates mainly formed cassettes carrying mec complex B, while the S.haemolyticus isolates had cassettes carrying classes C1 and C2 mec complex. Out of 9 isolates of S.hominis 5 isolates carried a new type cassette: class A mec complex in combination with the complex of the recombinase ccrl genes. SCCmec was not identified in S.capitis and S.pasteuri. Their representatives carried either mec complex (1 isolate of S.pasteuri) or the recombinase complexes (2 isolates of S.capitis). The detected SCCmec variants in CoNS could be a source of emergence of new genetic lines of MRSA. |
| format | Article |
| id | doaj-art-e39dadbccd104030aa08dfabb3b5d2d4 |
| institution | Matheson Library |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-e39dadbccd104030aa08dfabb3b5d2d42025-08-03T13:04:47ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01607-8310604Structural Polymorphism of Genome Islands Encoding Resistance to Beta-Lactams in Coagulase-Negative Staphylococci Isolated at Hospitals of the Russian FederationO. A. Dmitrenko0A. S. Ankirskaya1L. A. Lyubasovskaya2O. V. Kovalishena3D. A. Popov4V. V. Gostev5S. V. Sidorenko6N.F. Gamaleya Federal Research Centre of Epidemiology and Microbiology, Ministry of Public Health of the Russian FederationV.I. Kulakov Scientific Centre of Obstetries, Gynecology and Perinatology, Ministry of Public Health of the Russian FederationV.I. Kulakov Scientific Centre of Obstetries, Gynecology and Perinatology, Ministry of Public Health of the Russian FederationNizhegorodskaya State Medical Academy, Ministry of Public Health of the Russian FederationA.N. Bakulev Scientific Centre for Cardiovascular Surgery, Ministry of Public Health of the Russian FederationResearch Institute of Children's Infections, Federal Medical and Biological AgencyResearch Institute of Children's Infections, Federal Medical and Biological AgencyCoagulase-negative staphylococci (CoNS) are considered as a reservoir of mobile genetic elements and first of all of the staphylococcal cassette chromosome mec (SCCmec), defining staphylococci resistance to beta-lactams. Types II, IV, IVa, V, VII and VIII SCCmec were detected among 95 staphylococcal strains isolated in different regions of the Russian Federation. Subtypes Cla, Clb, Clc and Cl SCCmec were also identified (class B mec complex and two complexes of ccrl and ccr2 genes recombinases). Some other cassette types carrying A, C1 and C2 classes of the mec complexes in combination with various recombinase genes were detected. The S.epidermidis isolates mainly formed cassettes carrying mec complex B, while the S.haemolyticus isolates had cassettes carrying classes C1 and C2 mec complex. Out of 9 isolates of S.hominis 5 isolates carried a new type cassette: class A mec complex in combination with the complex of the recombinase ccrl genes. SCCmec was not identified in S.capitis and S.pasteuri. Their representatives carried either mec complex (1 isolate of S.pasteuri) or the recombinase complexes (2 isolates of S.capitis). The detected SCCmec variants in CoNS could be a source of emergence of new genetic lines of MRSA.https://www.antibiotics-chemotherapy.ru/jour/article/view/605coagulase-negative staphylococcimethicillin resistancestaphylococcal cassette chromosome mec |
| spellingShingle | O. A. Dmitrenko A. S. Ankirskaya L. A. Lyubasovskaya O. V. Kovalishena D. A. Popov V. V. Gostev S. V. Sidorenko Structural Polymorphism of Genome Islands Encoding Resistance to Beta-Lactams in Coagulase-Negative Staphylococci Isolated at Hospitals of the Russian Federation Антибиотики и Химиотерапия coagulase-negative staphylococci methicillin resistance staphylococcal cassette chromosome mec |
| title | Structural Polymorphism of Genome Islands Encoding Resistance to Beta-Lactams in Coagulase-Negative Staphylococci Isolated at Hospitals of the Russian Federation |
| title_full | Structural Polymorphism of Genome Islands Encoding Resistance to Beta-Lactams in Coagulase-Negative Staphylococci Isolated at Hospitals of the Russian Federation |
| title_fullStr | Structural Polymorphism of Genome Islands Encoding Resistance to Beta-Lactams in Coagulase-Negative Staphylococci Isolated at Hospitals of the Russian Federation |
| title_full_unstemmed | Structural Polymorphism of Genome Islands Encoding Resistance to Beta-Lactams in Coagulase-Negative Staphylococci Isolated at Hospitals of the Russian Federation |
| title_short | Structural Polymorphism of Genome Islands Encoding Resistance to Beta-Lactams in Coagulase-Negative Staphylococci Isolated at Hospitals of the Russian Federation |
| title_sort | structural polymorphism of genome islands encoding resistance to beta lactams in coagulase negative staphylococci isolated at hospitals of the russian federation |
| topic | coagulase-negative staphylococci methicillin resistance staphylococcal cassette chromosome mec |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/605 |
| work_keys_str_mv | AT oadmitrenko structuralpolymorphismofgenomeislandsencodingresistancetobetalactamsincoagulasenegativestaphylococciisolatedathospitalsoftherussianfederation AT asankirskaya structuralpolymorphismofgenomeislandsencodingresistancetobetalactamsincoagulasenegativestaphylococciisolatedathospitalsoftherussianfederation AT lalyubasovskaya structuralpolymorphismofgenomeislandsencodingresistancetobetalactamsincoagulasenegativestaphylococciisolatedathospitalsoftherussianfederation AT ovkovalishena structuralpolymorphismofgenomeislandsencodingresistancetobetalactamsincoagulasenegativestaphylococciisolatedathospitalsoftherussianfederation AT dapopov structuralpolymorphismofgenomeislandsencodingresistancetobetalactamsincoagulasenegativestaphylococciisolatedathospitalsoftherussianfederation AT vvgostev structuralpolymorphismofgenomeislandsencodingresistancetobetalactamsincoagulasenegativestaphylococciisolatedathospitalsoftherussianfederation AT svsidorenko structuralpolymorphismofgenomeislandsencodingresistancetobetalactamsincoagulasenegativestaphylococciisolatedathospitalsoftherussianfederation |