Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease
Aim: to determine the differences of ADMA level between stages 3, 4, and 5 non-dialysis of chronic kidney disease (CKD) patients at Outpatient Nephrology Clinic, Dr. Soetomo Hospital. Methods: a cross-sectional study was conducted on stage 3, 4, and 5 non-dialysis CKD patients at Outpatient Nephro...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2016-09-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://www.actamedindones.org/index.php/ijim/article/view/134 |
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| author | Tri P Asmarawati Widodo Widodo M Thaha Aditiawardana Aditiawardana Nunuk Mardiana Ardityo R Ardhany Artaria Tjempakasari Djoko Santoso Pranawa Pranawa Chandra Irwanadi |
| author_facet | Tri P Asmarawati Widodo Widodo M Thaha Aditiawardana Aditiawardana Nunuk Mardiana Ardityo R Ardhany Artaria Tjempakasari Djoko Santoso Pranawa Pranawa Chandra Irwanadi |
| author_sort | Tri P Asmarawati |
| collection | DOAJ |
| description | Aim: to determine the differences of ADMA level between stages 3, 4, and 5 non-dialysis of chronic kidney
disease (CKD) patients at Outpatient Nephrology Clinic, Dr. Soetomo Hospital. Methods: a cross-sectional
study was conducted on stage 3, 4, and 5 non-dialysis CKD patients at Outpatient Nephrology Clinic, Dr.
Soetomo Hospital, Surabaya from January to February 2015. Stages of CKD were determined based on GFR
estimation according to 4-variable MDRD formula. Statistical analysis of differences in the levels of ADMA in
three subject groups use one-way ANOVA test. Results:seventy-five patients were included in the study. Each
group consisted of 25 patients stage 3, 4, and, 5 non-dialysis patients. Mean age of stage 3, stage 4, and stage
5 non-dialysis CKD patients were respectively 57.12 years, 54.80 years and 53.68 years. The mean levels of
ADMA in stage 3, stage 4, and 5 were 0.62 (0.11) IU/mL, 0.72 (0.16) IU/mL, and 0.73 (0.18) IU/mL respectively.
Analysis of the differences between the groups showed significant differences in ADMA levels (p=0.04), with the
highest difference between stage 3 and stage 5. Conclusion:comparison of ADMA levels showed significant
differences between CKD stages and the level tends to be higher along with increase severity of CKD stages. |
| format | Article |
| id | doaj-art-e3749e4b15e14ddda16f13789b869d7f |
| institution | Matheson Library |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-e3749e4b15e14ddda16f13789b869d7f2025-07-23T07:02:54ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322016-09-01481131Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney DiseaseTri P Asmarawati0Widodo Widodo1M Thaha2Aditiawardana Aditiawardana3Nunuk Mardiana4Ardityo R Ardhany5Artaria Tjempakasari6Djoko Santoso7Pranawa Pranawa8Chandra Irwanadi9Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaAim: to determine the differences of ADMA level between stages 3, 4, and 5 non-dialysis of chronic kidney disease (CKD) patients at Outpatient Nephrology Clinic, Dr. Soetomo Hospital. Methods: a cross-sectional study was conducted on stage 3, 4, and 5 non-dialysis CKD patients at Outpatient Nephrology Clinic, Dr. Soetomo Hospital, Surabaya from January to February 2015. Stages of CKD were determined based on GFR estimation according to 4-variable MDRD formula. Statistical analysis of differences in the levels of ADMA in three subject groups use one-way ANOVA test. Results:seventy-five patients were included in the study. Each group consisted of 25 patients stage 3, 4, and, 5 non-dialysis patients. Mean age of stage 3, stage 4, and stage 5 non-dialysis CKD patients were respectively 57.12 years, 54.80 years and 53.68 years. The mean levels of ADMA in stage 3, stage 4, and 5 were 0.62 (0.11) IU/mL, 0.72 (0.16) IU/mL, and 0.73 (0.18) IU/mL respectively. Analysis of the differences between the groups showed significant differences in ADMA levels (p=0.04), with the highest difference between stage 3 and stage 5. Conclusion:comparison of ADMA levels showed significant differences between CKD stages and the level tends to be higher along with increase severity of CKD stages.https://www.actamedindones.org/index.php/ijim/article/view/134chronic kidney diseaseasymmetric dimethylarginine (ADMA)cardiovascular disease |
| spellingShingle | Tri P Asmarawati Widodo Widodo M Thaha Aditiawardana Aditiawardana Nunuk Mardiana Ardityo R Ardhany Artaria Tjempakasari Djoko Santoso Pranawa Pranawa Chandra Irwanadi Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease Acta Medica Indonesiana chronic kidney disease asymmetric dimethylarginine (ADMA) cardiovascular disease |
| title | Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease |
| title_full | Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease |
| title_fullStr | Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease |
| title_full_unstemmed | Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease |
| title_short | Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease |
| title_sort | comparison of asymmetric dimethylarginine levels between stages three four and five non dialysis of chronic kidney disease |
| topic | chronic kidney disease asymmetric dimethylarginine (ADMA) cardiovascular disease |
| url | https://www.actamedindones.org/index.php/ijim/article/view/134 |
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