An autologous blood-derived patch as an antiadhesive in a porcine uterine horn model
Background: Post-surgical adhesions, i.e., scar tissue inadvertently interlinking organs in the abdomen, is a common complication after surgery that can lead to infertility, small bowel obstruction and difficulties in subsequent surgeries. We explored an autologous method for preventing adhesions. M...
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Elsevier
2025-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402502002X |
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| author | Morten PR. Eskildsen Otto Kalliokoski Marie Boennelycke Rasmus Lundquist Annette Settnes Ellen Loekkegaard |
| author_facet | Morten PR. Eskildsen Otto Kalliokoski Marie Boennelycke Rasmus Lundquist Annette Settnes Ellen Loekkegaard |
| author_sort | Morten PR. Eskildsen |
| collection | DOAJ |
| description | Background: Post-surgical adhesions, i.e., scar tissue inadvertently interlinking organs in the abdomen, is a common complication after surgery that can lead to infertility, small bowel obstruction and difficulties in subsequent surgeries. We explored an autologous method for preventing adhesions. Methods: An autologous blood-derived patch, purely made from the patient's own blood, was tested in a porcine model. We performed laparotomies, damaged the uterine horns, positioned and fixed them in close proximity to a denuded area on the abdominal wall. One uterine horn was protected with a patch (n = 11), the other acted as an untreated control. Four weeks after the surgery, adhesions were assessed macroscopically and microscopically. Results: Uterine horns treated with a patch had significantly fewer and less severe adhesions. Furthermore, less inflammation and less intramural and peritoneal fibrosis was found in the patch-treated uterine horns. Conclusions: We conclude that treatment with the blood-derived patch has potential for preventing post-surgical adhesions. |
| format | Article |
| id | doaj-art-e3728aacf9ea4f6a8d7c6be60a31e6f1 |
| institution | Matheson Library |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-e3728aacf9ea4f6a8d7c6be60a31e6f12025-07-17T04:44:37ZengElsevierHeliyon2405-84402025-08-011113e43616An autologous blood-derived patch as an antiadhesive in a porcine uterine horn modelMorten PR. Eskildsen0Otto Kalliokoski1Marie Boennelycke2Rasmus Lundquist3Annette Settnes4Ellen Loekkegaard5Department of Obstetrics and Gynecology, Copenhagen University Hospital–North Zealand, Hilleroed, Denmark; Department of Experimental Medicine, University of Copenhagen, Copenhagen, Denmark; Corresponding author. North Zealand Hospital, Dyrehavevej 29, 3400, Hilleroed, Denmark.Department of Experimental Medicine, University of Copenhagen, Copenhagen, DenmarkDepartment of Pathology, Copenhagen University Hospital–Rigshospitalet, Copenhagen, DenmarkReapplix A/S, Birkeroed, DenmarkDepartment of Obstetrics and Gynecology, Copenhagen University Hospital–North Zealand, Hilleroed, DenmarkDepartment of Obstetrics and Gynecology, Copenhagen University Hospital–North Zealand, Hilleroed, DenmarkBackground: Post-surgical adhesions, i.e., scar tissue inadvertently interlinking organs in the abdomen, is a common complication after surgery that can lead to infertility, small bowel obstruction and difficulties in subsequent surgeries. We explored an autologous method for preventing adhesions. Methods: An autologous blood-derived patch, purely made from the patient's own blood, was tested in a porcine model. We performed laparotomies, damaged the uterine horns, positioned and fixed them in close proximity to a denuded area on the abdominal wall. One uterine horn was protected with a patch (n = 11), the other acted as an untreated control. Four weeks after the surgery, adhesions were assessed macroscopically and microscopically. Results: Uterine horns treated with a patch had significantly fewer and less severe adhesions. Furthermore, less inflammation and less intramural and peritoneal fibrosis was found in the patch-treated uterine horns. Conclusions: We conclude that treatment with the blood-derived patch has potential for preventing post-surgical adhesions.http://www.sciencedirect.com/science/article/pii/S240584402502002XAutologousBlood-derivedAntiadhesiveCombined leukocyte platelet and fibrin patchUterine horn model |
| spellingShingle | Morten PR. Eskildsen Otto Kalliokoski Marie Boennelycke Rasmus Lundquist Annette Settnes Ellen Loekkegaard An autologous blood-derived patch as an antiadhesive in a porcine uterine horn model Heliyon Autologous Blood-derived Antiadhesive Combined leukocyte platelet and fibrin patch Uterine horn model |
| title | An autologous blood-derived patch as an antiadhesive in a porcine uterine horn model |
| title_full | An autologous blood-derived patch as an antiadhesive in a porcine uterine horn model |
| title_fullStr | An autologous blood-derived patch as an antiadhesive in a porcine uterine horn model |
| title_full_unstemmed | An autologous blood-derived patch as an antiadhesive in a porcine uterine horn model |
| title_short | An autologous blood-derived patch as an antiadhesive in a porcine uterine horn model |
| title_sort | autologous blood derived patch as an antiadhesive in a porcine uterine horn model |
| topic | Autologous Blood-derived Antiadhesive Combined leukocyte platelet and fibrin patch Uterine horn model |
| url | http://www.sciencedirect.com/science/article/pii/S240584402502002X |
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