An autologous blood-derived patch as an antiadhesive in a porcine uterine horn model
Background: Post-surgical adhesions, i.e., scar tissue inadvertently interlinking organs in the abdomen, is a common complication after surgery that can lead to infertility, small bowel obstruction and difficulties in subsequent surgeries. We explored an autologous method for preventing adhesions. M...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402502002X |
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| Summary: | Background: Post-surgical adhesions, i.e., scar tissue inadvertently interlinking organs in the abdomen, is a common complication after surgery that can lead to infertility, small bowel obstruction and difficulties in subsequent surgeries. We explored an autologous method for preventing adhesions. Methods: An autologous blood-derived patch, purely made from the patient's own blood, was tested in a porcine model. We performed laparotomies, damaged the uterine horns, positioned and fixed them in close proximity to a denuded area on the abdominal wall. One uterine horn was protected with a patch (n = 11), the other acted as an untreated control. Four weeks after the surgery, adhesions were assessed macroscopically and microscopically. Results: Uterine horns treated with a patch had significantly fewer and less severe adhesions. Furthermore, less inflammation and less intramural and peritoneal fibrosis was found in the patch-treated uterine horns. Conclusions: We conclude that treatment with the blood-derived patch has potential for preventing post-surgical adhesions. |
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| ISSN: | 2405-8440 |