The APOE–Microglia Axis in Alzheimer’s Disease: Functional Divergence and Therapeutic Perspectives—A Narrative Review

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The APOE–Microglia Axis in Alzheimer’s Disease: Functional Divergence and Therapeutic Perspectives—A Narrative Review

Apolipoprotein E (APOE) alleles play distinct roles in the pathogenesis of Alzheimer’s disease (AD), with <i>APOE</i>ε4 being the strongest genetic risk factor for late-onset AD, while <i>APOE</i>ε2 appears protective. Despite extensive research, the precise mechanisms by whi...

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Bibliographic Details
Main Authors:	Aiwei Liu, Tingxu Wang, Liu Yang, Yu Zhou
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Brain Sciences
Subjects:	Alzheimer’s disease apolipoprotein E microglia inflammation phagocytosis lipid metabolism
Online Access:	https://www.mdpi.com/2076-3425/15/7/675
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