Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19
The aim was to analyze the prognostic value of ventilation/ gas exchange dissociation markers to predict the treatment length in patients with the acute phase of COVID-19.Materials and methods: The analysis was performed using a database of 384 randomly selected patients from December 2021 to May 20...
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| Language: | Russian |
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Journal Infectology
2024-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/1664 |
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| author | E. S. Pan’ko S. V. Zhavoronok A. M. Solovchuk S. V. Pan’ko |
| author_facet | E. S. Pan’ko S. V. Zhavoronok A. M. Solovchuk S. V. Pan’ko |
| author_sort | E. S. Pan’ko |
| collection | DOAJ |
| description | The aim was to analyze the prognostic value of ventilation/ gas exchange dissociation markers to predict the treatment length in patients with the acute phase of COVID-19.Materials and methods: The analysis was performed using a database of 384 randomly selected patients from December 2021 to May 2022 with a confirmed diagnosis of the acute phase of COVID-19, aged 61±16 years. Spirometry of maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) was performed on 2,2±0,2 day of hospitalization with a portable MicroRPM device (CareFusion, UK) and measurement of surrogate oxygenation index (SpO2/FiO2), ROX index (SpO2/ FiO2)/respiratory rate) was carried out in all patients. Log-regression models were used (STATISTICA 10) to determine cutoff values for these functional variables and their ability to predict the patients length of hospital stay from the date of examination (≤ 7 vs > 7 days).Results: The lowest sensitivity (SE) and specificity (SP) were shown in models using only the respiratory muscle strength markers MIP (SE=54%, SP=70%) and MEP (SE=73%, SP=47%), that were the same in the combination of MIP and MEP (SE=65%, SP=58%). The areas under ROC were equal to 0.6 in all three models. The models based on hypoxia markers had a higher classification power (AUC 0,7) compared to the previous three, and the sensitivity value was higher in the model using the ROX index (SE = 58% and SP = 78%), but the specificity was better in the surrogate oxygenation index model (SE = 48% and SP = 88%). A complex model based on a combination of the two integral hypoxia indices, as well as a diaphragm strength marker (SpO2/FiO2+MIP*ROX+MIP) had the best sensitivity (67%) and specificity (84%), and the area under ROC reached 0.8.Conclusion: Indicators of respiratory muscle strength and oxygenation are suitable markers for combined models and algorithms for predicting hospital length of stay in COVID-19 patients. |
| format | Article |
| id | doaj-art-e3388087c0e24a5280e7f3491a3d5058 |
| institution | Matheson Library |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2024-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-e3388087c0e24a5280e7f3491a3d50582025-08-04T14:25:49ZrusJournal InfectologyЖурнал инфектологии2072-67322024-09-01163717910.22625/2072-6732-2024-16-3-71-791164Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19E. S. Pan’ko0S. V. Zhavoronok1A. M. Solovchuk2S. V. Pan’ko3Brest Regional Clinical HospitalBelarusian State Medical UniversityBrest State Technical UniversityBrest State University named after A.S. PushkinThe aim was to analyze the prognostic value of ventilation/ gas exchange dissociation markers to predict the treatment length in patients with the acute phase of COVID-19.Materials and methods: The analysis was performed using a database of 384 randomly selected patients from December 2021 to May 2022 with a confirmed diagnosis of the acute phase of COVID-19, aged 61±16 years. Spirometry of maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) was performed on 2,2±0,2 day of hospitalization with a portable MicroRPM device (CareFusion, UK) and measurement of surrogate oxygenation index (SpO2/FiO2), ROX index (SpO2/ FiO2)/respiratory rate) was carried out in all patients. Log-regression models were used (STATISTICA 10) to determine cutoff values for these functional variables and their ability to predict the patients length of hospital stay from the date of examination (≤ 7 vs > 7 days).Results: The lowest sensitivity (SE) and specificity (SP) were shown in models using only the respiratory muscle strength markers MIP (SE=54%, SP=70%) and MEP (SE=73%, SP=47%), that were the same in the combination of MIP and MEP (SE=65%, SP=58%). The areas under ROC were equal to 0.6 in all three models. The models based on hypoxia markers had a higher classification power (AUC 0,7) compared to the previous three, and the sensitivity value was higher in the model using the ROX index (SE = 58% and SP = 78%), but the specificity was better in the surrogate oxygenation index model (SE = 48% and SP = 88%). A complex model based on a combination of the two integral hypoxia indices, as well as a diaphragm strength marker (SpO2/FiO2+MIP*ROX+MIP) had the best sensitivity (67%) and specificity (84%), and the area under ROC reached 0.8.Conclusion: Indicators of respiratory muscle strength and oxygenation are suitable markers for combined models and algorithms for predicting hospital length of stay in COVID-19 patients.https://journal.niidi.ru/jofin/article/view/1664covid-19sars-cov-2spirometrymaximal respiratory pressuresspo2/fio2 ratiorox indexpredictive modelalgorithm |
| spellingShingle | E. S. Pan’ko S. V. Zhavoronok A. M. Solovchuk S. V. Pan’ko Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19 Журнал инфектологии covid-19 sars-cov-2 spirometry maximal respiratory pressures spo2/fio2 ratio rox index predictive model algorithm |
| title | Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19 |
| title_full | Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19 |
| title_fullStr | Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19 |
| title_full_unstemmed | Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19 |
| title_short | Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19 |
| title_sort | respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with covid 19 |
| topic | covid-19 sars-cov-2 spirometry maximal respiratory pressures spo2/fio2 ratio rox index predictive model algorithm |
| url | https://journal.niidi.ru/jofin/article/view/1664 |
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