METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

Hepatocellular carcinoma (HCC) is among the most common causes of cancer‐related deaths worldwide. Previous studies showed that N6‐methyladenosine (m6A), the most abundant chemical modification in eukaryotic RNAs, is implicated in HCC progression. Using liver‐specific conditional knockout mice, we f...

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Bibliografiske detaljer
Main Authors: Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu
Format: Article
Sprog:engelsk
Udgivet: Wiley 2025-07-01
Serier:FEBS Open Bio
Fag:
ER stress response
hepatocarcinogenesis
hepatocellular carcinoma
m6A
METTL3
Online adgang:https://doi.org/10.1002/2211-5463.70023
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