Free water as a potential mediator linking basal ganglia peri-vascular spaces to white matter hyperintensities in cerebral small vessel disease

Free water as a potential mediator linking basal ganglia peri-vascular spaces to white matter hyperintensities in cerebral small vessel disease

ObjectiveWhite matter hyperintensities (WMH) are common in cerebral small vessel disease (CSVD) and have been linked to an increased risk of stroke and cognitive impairment. Emerging evidence suggests that perivascular spaces (PVS) and impaired interstitial fluid (ISF) drainage may contribute to WMH...

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Bibliographic Details
Main Authors: Weishun Feng, Xinjun Lei, Xinbin Wang, Shida Xu, Zhihua Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neuroscience
Subjects:
white matter hyperintensity
perivascular space
free water
interstitial fluid
cerebral small vessel disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1621023/full
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